NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells.

	NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells.
	Youhai Chen; Jiacheng Bi; Lulu Cui; Guang Yu; Xiaolu Yang; Xiaochun Wan
刊名	JOURNAL OF IMMUNOLOGY
	2017
文献子类	期刊论文
英文摘要	Group 2 innate lymphoid cells (ILC2s) play an important role in orchestrating type II immune responses. However, the cellular mechanisms of group 2 innatelymphoid cell regulation remain poorly understood. In this study, we found that activated NK cells inhibited the proliferation of, as well as IL-5 and IL-13 production by, ILC2s in vitro via IFN-gamma. In addition, in a murine model of ILC2 expansion in the liver, polyinosinic-polycytidylic acid, an NK cell-activating agent, inhibited ILC2 proliferation, IL-5 and IL-13 production, and eosinophil recruitment. Such effects of polyinosinic-polycytidylic acid were abrogated in NKcell-depleted mice and in IFN-gamma-deficient mice. Adoptively transferring wild-type NK cells into NK cell-depleted mice resulted in fewer ILC2s induced byIL-33 compared with the transfer of IFN-g-deficient NK cells. Importantly, during the early stage of papain-or bleomycin-induced lung inflammation, depletion of NK cells resulted in increased ILC2 numbers and enhanced cytokine production by ILC2s, as well as aggravated eosinophilia and goblet cell hyperplasia. Collectively, these data show that NK cells negatively regulate ILC2s during the early stage of lung inflammation, which represents the novel cellular interaction between two family members of ILCs.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12276]
专题	深圳先进技术研究院_医药所
作者单位	JOURNAL OF IMMUNOLOGY
推荐引用方式 GB/T 7714	Youhai Chen,Jiacheng Bi,Lulu Cui,et al. NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells.[J]. JOURNAL OF IMMUNOLOGY,2017.
APA	Youhai Chen,Jiacheng Bi,Lulu Cui,Guang Yu,Xiaolu Yang,&Xiaochun Wan.(2017).NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells..JOURNAL OF IMMUNOLOGY.
MLA	Youhai Chen,et al."NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells.".JOURNAL OF IMMUNOLOGY (2017).