Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance

	Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance
	Ruijing Liang; Aiqing Ma; Ze Chen; Mingbin Zheng; Lanlan Liu; Zhenyu Luo; Hao Tian; Zhiqun Han; Chengyu Lu; Lintao Cai
刊名	Advanced Functional Materials
	2017
文献子类	期刊论文
英文摘要	The inadequate oxygen supply in solid tumor causes hypoxia, which leads to drug resistance and poor chemotherapy outcomes. To solve this problem, a cancer cell membrane camouflaged nanocarrier is developed with a polymeric core encapsulating hemoglobin (Hb) and doxorubicin (DOX) for efficient chemotherapy. The designed nanoparticles (DHCNPs) retain the cancer cell adhesion molecules on the surface of nanoparticles for homologous targeting and possess the oxygen-carrying capacity of Hb for O2-interfered chemotherapy. The results show that DHCNPs not only achieve higher tumor specificity and lower toxicity by homologous targeting but also significantly reduce the exocytosis of DOX via suppressing the expressions of hypoxia-inducible factor-1α, multidrug resistance gene 1, and P-glycoprotein, thus resulting in safe and high-efficient chemotherapy. This work presents a new paradigm for targeted oxygen interference therapy by conquering hypoxia-involved therapeutic resistance and achieves effective treatment of solid tumors.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12264]
专题	深圳先进技术研究院_医药所
作者单位	Advanced Functional Materials
推荐引用方式 GB/T 7714	Ruijing Liang,Aiqing Ma,Ze Chen,et al. Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance[J]. Advanced Functional Materials,2017.
APA	Ruijing Liang.,Aiqing Ma.,Ze Chen.,Mingbin Zheng.,Lanlan Liu.,...&Lintao Cai.(2017).Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance.Advanced Functional Materials.
MLA	Ruijing Liang,et al."Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance".Advanced Functional Materials (2017).