Bovine Serum Albumin-Loaded Nano-selenium/ICG Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy

	Bovine Serum Albumin-Loaded Nano-selenium/ICG Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy
	Guanjun Deng; Wenjun Li; Xiaoqing Meng; Jiazheng Lai; Zhihong Sun; Sanpeng Li; Jingnan Zhang; Lihua Zhou; Ting Zhu; Pengfei zhang
刊名	RSC Advances
	2017
文献子类	期刊论文
英文摘要	A combination of chemotherapy and photothermal treatment has already become a promising strategy for cancer treatment. Hence, it is highly desirable to develop a safe and effective delivery system. In the present study, we have developed a bovine serum albumin loaded nano-selenium(SeNPs)/Indocyanine green (ICG) nanoparticles (BSINPs) that was generated by a programmed assembly method. It could deliver SeNPs (chemotherapeutic agent) and ICG (photothermal agent) to tumor regions for combined chemo-photothermal therapy simultaneously. BSINPs presented good monodispersity, well size/fluorescence stability, and unanimous spectra feature in comparison with free ICG. Moreover, the BSINPs displayed a longer retention time in tumor and higher temperature response under laser irradiation. Meanwhile, BSINPs were able to monitor the process of subcellular location in vitro and the distribution of particles in vivo. The combined therapy of BSINPs with laser irradiation synergistically induced the death of U87L glioma cells, and completely inhibited U87L tumor growth in vivo compared with chemo or photothermal therapy alone. Outstandingly, no tumor recurrence and treatments-induced toxicity were observed after only a single-dose of BSINPs with laser irradiation. The results indicate that the well-defined BSINPs is highly desirable for cancer treatment with chemo-photothermal therapy.
URL标识	查看原文
语种	英语
WOS记录号	WOS:000403668900026
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12257]
专题	深圳先进技术研究院_医药所
作者单位	RSC Advances
推荐引用方式 GB/T 7714	Guanjun Deng,Wenjun Li,Xiaoqing Meng,et al. Bovine Serum Albumin-Loaded Nano-selenium/ICG Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy[J]. RSC Advances,2017.
APA	Guanjun Deng.,Wenjun Li.,Xiaoqing Meng.,Jiazheng Lai.,Zhihong Sun.,...&Lintao Cai.(2017).Bovine Serum Albumin-Loaded Nano-selenium/ICG Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy.RSC Advances.
MLA	Guanjun Deng,et al."Bovine Serum Albumin-Loaded Nano-selenium/ICG Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy".RSC Advances (2017).