Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model.

	Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model.
	Chen, Shihui; Lau, Poying; Lei, Ming; Peng, Jiang; Tang, Tao; Wang, Xiaohong; Qin, Ling; Kumta, Shekhar-Madhukar
刊名	JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
	2017
文献子类	期刊论文
英文摘要	A functional biomaterial with a therapeutic effect is desirable as an adjuvant therapy to enhance bone formation and prevent local recurrence of bone tumours, especially when the resection margins are not identifiable. In this study, novel composite materials were developed with dual properties of osteopromotion and bone resorption to mimic the tumour inhibition effect, including water-soluble phosphorylated chitosan (P-chitosan) for increasing osteoblasts activity and disodium (14)-2-deoxy-2-sulphoamino--d-glucopyranuronan (S-chitosan) for inhibiting bone resorption activity. First, P-chitosan and S-chitosan were respectively incorporated into two kinds of PLGA/TCP-based scaffold, i.e. PLGA-TCP-P-chitosan (P/T/P-chitosan) and PLGA-TCP-S-chitosan (P/T/S-chitosan) scaffolds. We subsequently tested combined scaffolds of PLGA-TCP-P-S-P-chitosan (P/T/PSP-chitosan) made of P/T/P-chitosan and P/T/S-chitosan to assess their integral effect, on enhancement of bone formation with P/T/P-chitosan and inhibition of tissue regeneration with P/T/S-chitosan, in an established rabbit ulnar bone defect model to imitate bone resection post-bone tumour. To compare bone healing in the defects, the P/T/P-chitosan group was regarded as a bone formation enhancement group, while the P/T group served as a control. Bone mineral density (BMD) in the P/T/P-chitosan and P/T/PSP-chitosan groups were found to be significantly higher than those in the P/T group, while that in the P/T/P-chitosan group was greater than that in the P/T/PSP-chitosan group (p<0.05). These findings demonstrated that P/T/PSP-chitosan scaffolds possessed more osteogenic potential than the P/T scaffold but less osteogenic effect than the P/T/P-chitosan scaffold, as the S-chitosan component inhibited the activities of osteoblasts for bone formation. These findings implied a dual function of the designed P/T/PSP-chitosan for further preclinical validation and potential applications in the prevention of local recurrence and for enhancing bone repair after bone tumour resection. Copyright (c) 2013 John Wiley & Sons, Ltd.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12158]
专题	深圳先进技术研究院_医工所
作者单位	JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
推荐引用方式 GB/T 7714	Chen, Shihui,Lau, Poying,Lei, Ming,et al. Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model.[J]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2017.
APA	Chen, Shihui.,Lau, Poying.,Lei, Ming.,Peng, Jiang.,Tang, Tao.,...&Kumta, Shekhar-Madhukar.(2017).Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model..JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE.
MLA	Chen, Shihui,et al."Segmental composite porous scaffolds with either osteogenesis or anti-bone resorption properties tested in a rabbit ulna defect model.".JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017).