Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography.

	Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography.
	Guillaume, O. ; Geven, M. A. ; Grijpma, D. W. ; Tang, T. T. ; Qin, L. ; Lai, Y. X. ; Yuan, H. ; Richards, R. G. ; Eglin, D.
刊名	POLYMERS FOR ADVANCED TECHNOLOGIES
	2017
文献子类	期刊论文
英文摘要	Designing calcium phosphate-loaded polymeric porous scaffolds with controlled architecture using stereolithography (SLA) has great potential in the field of bone tissue engineering. However, the use of poly(ester)s with suboptimal degradation property has mainly been reported. In the present work, we introduced a poly(trimethylene carbonate) (PTMC) and nano-hydroxyapatite (HA) resin suitable for SLA manufacturing and created cytocompatible 3D porous structure. First, the resin formulation and HA content were optimized for photo-crosslink-based SLA fabrication process. Subsequently, we evaluated the influence of the resin composition on physico-chemical characteristics of fabricated films and scaffolds. Then, the influence of the biomaterial composition on human bone marrow mesenchymal stem cell viability, adhesion and proliferation was assessed. Films and macroporous scaffolds were successfully produced by photo-crosslinking with up to 40wt% of HA (relative to PTMC). We demonstrated that addition of HA in PTMC matrices induced a direct effect on the surface properties, in terms of wettability and topography. Additionally, mechanical tests revealed a correlation between the amounts of HA loaded in PTMC and the stiffness of the SLA-fabricated scaffolds. Importantly, the different photo-crosslinked biomaterials exhibited in vitro cytocompatibility, similar to tissue culture polystyrene. Those data suggest the possibility to fabricate highly tunable HA-loaded PTMC 3D porous structures for bone tissue engineering application. Copyright (c) 2016 John Wiley & Sons, Ltd.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12150]
专题	深圳先进技术研究院_医工所
作者单位	POLYMERS FOR ADVANCED TECHNOLOGIES
推荐引用方式 GB/T 7714	Guillaume, O. , Geven, M. A. , Grijpma, D. W. ,et al. Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography.[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2017.
APA	Guillaume, O. ., Geven, M. A. ., Grijpma, D. W. ., Tang, T. T. ., Qin, L. .,...& Eglin, D..(2017).Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography..POLYMERS FOR ADVANCED TECHNOLOGIES.
MLA	Guillaume, O. ,et al."Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography.".POLYMERS FOR ADVANCED TECHNOLOGIES (2017).