Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma

	Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma
	Mingting Zhu; Zonghai Sheng; Yali Jia; Dehong Hu; Xin Liu; Xianyuan Xia; Chengbo Liu; Pan Wang; Xiaobing Wang; and Hairong Zheng
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017
文献子类	期刊论文
英文摘要	Active-targeted cancer imaging and therapy of glioma has attracted much attention in theranostic nanomedicine. As a promising tumor-targeting ligand, holotransferrin (holo-Tf) has been applied for enhancing delivery of nanotheranostics. However, holo-Tf-based nanoassemblies for active targeting mediated multimodal imaging and therapeutics have not been previously reported. Here, we develop a one-step method for the preparation of holo-Tf-indocyaninegreen (holo-Tf-ICG) nanoassemblies for fluorescence (FL) and photoacoustic (PA) dual-modal imaging and photothermal therapy (PTT) of glioma. The nanoassemblies are formed by hydrophobic interaction and hydrogen bonds between holo-Tf and ICG, which exhibit excellent active tumor-targeting and high biocompability. The brain tumor with highly expressed Tf receptor can be clearly observed with holo-Tf-ICG nanoassemblies base on FL and PA dual-modalimaging in subcutaneous and orthotopic glioma models. Under the near-infrared laser irradiation, the holo-Tf-ICG nanoassemblies accumulated in tumor regions can efficiently convert laser energy into hyperthermia for tumor ablation. The novel theranostic nanoplatform holds great promise for precision diagnosis and treatment of glioma.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/12106]
专题	深圳先进技术研究院_医工所
作者单位	ACS APPLIED MATERIALS & INTERFACES
推荐引用方式 GB/T 7714	Mingting Zhu,Zonghai Sheng,Yali Jia,et al. Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma[J]. ACS APPLIED MATERIALS & INTERFACES,2017.
APA	Mingting Zhu.,Zonghai Sheng.,Yali Jia.,Dehong Hu.,Xin Liu.,...&and Hairong Zheng.(2017).Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma.ACS APPLIED MATERIALS & INTERFACES.
MLA	Mingting Zhu,et al."Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma".ACS APPLIED MATERIALS & INTERFACES (2017).