Valency-Controlled Framework Nucleic Acid Signal Amplifiers

doi:10.1002/anie.201802701

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Valency-Controlled Framework Nucleic Acid Signal Amplifiers
	Liu, Q ; Ge, ZL ; Mao, XH ; Zhou, GB ; Zuo, XL ; Shen, JW ; Shi, JY ; Li, J ; Wang, LH ; Chen, XQ
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2018
卷号	57 期号:24 页码:7131-7135
关键词	Hybridization Chain-reaction Tetrahedral Dna Nanostructure Gold Nanoparticles Messenger-rna Electrochemical Detection Inorganic Nanomaterials Reaction Amplification Biomolecular Detection Biosensing Interface Gene-expression
ISSN号	1433-7851
DOI	10.1002/anie.201802701
文献子类	期刊论文
英文摘要	Weak ligand-receptor recognition events are often amplified by recruiting multiple regulatory biomolecules to the action site in biological systems. However, signal amplification in invitro biomimetic systems generally lack the spatiotemporal regulation invivo. Herein we report a framework nucleic acid (FNA)-programmed strategy to develop valence-controlled signal amplifiers with high modularity for ultrasensitive biosensing. We demonstrated that the FNA-programmed signal amplifiers could recruit nucleic acids, proteins, and inorganic nanoparticles in a stoichiometric manner. The valence-controlled signal amplifier enhanced the quantification ability of electrochemical biosensors, and enabled ultrasensitive detection of tumor-relevant circulating free DNA (cfDNA) with sensitivity enhancement of 3-5 orders of magnitude and improved dynamic range.
语种	英语
WOS记录号	WOS:000434350400027
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/29206]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Liu, Q 2.Ge, ZL 3.Mao, XH 4.Zhou, GB 5.Zuo, XL 6.Shen, JW 7.Shi, JY 8.Li, J 9.Wang, LH 10.Chen, XQ
推荐引用方式 GB/T 7714	Liu, Q,Ge, ZL,Mao, XH,et al. Valency-Controlled Framework Nucleic Acid Signal Amplifiers[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(24):7131-7135.
APA	Liu, Q.,Ge, ZL.,Mao, XH.,Zhou, GB.,Zuo, XL.,...&Fan, CH.(2018).Valency-Controlled Framework Nucleic Acid Signal Amplifiers.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(24),7131-7135.
MLA	Liu, Q,et al."Valency-Controlled Framework Nucleic Acid Signal Amplifiers".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.24(2018):7131-7135.