Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure

doi:10.1021/acsami.8b02626

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure
	Xia, K ; Kong, HT ; Cui, YZ ; Ren, N ; Li, QN ; Ma, JF ; Cui, RR ; Zhang, Y ; Shi, JY ; Li, Q
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018
卷号	10 期号:18 页码:15442-15448
关键词	Drug-delivery Nanoparticle-uptake Gold Nanoparticles Origami Nanotechnology Accumulation Resistance Pathways Carrier Range
ISSN号	1944-8244
DOI	10.1021/acsami.8b02626
文献子类	期刊论文
英文摘要	The advent of DNA technology has demonstrated great potential in a wide range of applications, especially in the field of biology and biomedicine. However, current understanding of the toxicological effects and cellular responses of DNA nanostructures remains to be improved. Here, we chose tetrahedral DNA nanostructures (TDNs), a type of nanocarriers for delivering molecular drugs, as a model for systematic live-cell analysis of the biocompatibility of TDNs to normal bronchial epithelial cells, carcinoma cells, and macrophage. We found that the interaction behaviors of TDNs in different cell lines were very different, whereas after internalization, most of the TDNs in diverse cell lines were positioned to lysosomes. By a systematic assessment of cell responses after TDN exposure to various cells, we demonstrate that internalized TDNs have good innate biocompatibility. Interestingly, we found that TDN-bearing cells would not affect the cell cycle progression and accompany cell division and that TDNs were separated equally into two daughter cells. This study improves our understanding of the interaction of DNA nanostructures with living systems and their biocompatibility, which will be helpful for further designing DNA nanostructures for biomedical applications.
语种	英语
WOS记录号	WOS:000432205800014
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/29164]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Xia, K 2.Kong, HT 3.Cui, YZ 4.Ren, N 5.Li, QN 6.Ma, JF 7.Cui, RR 8.Zhang, Y 9.Shi, JY 10.Li, Q
推荐引用方式 GB/T 7714	Xia, K,Kong, HT,Cui, YZ,et al. Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(18):15442-15448.
APA	Xia, K.,Kong, HT.,Cui, YZ.,Ren, N.,Li, QN.,...&Zhu, Y.(2018).Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure.ACS APPLIED MATERIALS & INTERFACES,10(18),15442-15448.
MLA	Xia, K,et al."Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure".ACS APPLIED MATERIALS & INTERFACES 10.18(2018):15442-15448.