pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time

doi:10.1016/j.biomaterials.2018.04.002

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time
	Jiang, ZQ ; Tian, YC ; Shan, DY ; Wang, YJ ; Gerhard, E ; Xia, JB ; Huang, R ; He, Y ; Li, AG ; Tang, JC
刊名	BIOMATERIALS
	2018
卷号	170 页码:70-81
关键词	Neuropeptide-y Analog Drug-delivery Breast-cancer In-vivo Photodynamic Therapy Combination Therapy Antitumor-activity Sensitive Peptide Anticancer Drug Cellular Uptake
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2018.04.002
文献子类	期刊论文
英文摘要	Nanoparticle-based tumor therapies are extensively studied; however, few are capable of improving patient survival time due to premature drug leakage, off target effects, and poor tissue penetration. Previously, we successfully synthesized a novel family of Y-1 receptor (Y1R) ligand modified, photo luminescent BPLP nanobubbles and nanoparticles for targeted breast cancer ultrasound imaging; however, increased accumulation could also be observed in the liver, kidney, and spleen, suggesting significant interaction of the particles with macrophages in vivo. Herein, for the first time, we imparted antiphagocytosis capability to Y1R ligand functionalized BPLP-WPU polymeric micelles through the incorporation of a CD47 human glycoprotein based self-peptide. Application of self-peptide modified, DOX loaded micelles in vivo resulted in a 100% survival rate and complete tumor necrosis over 100 days of treatment. In vivo imaging of SPION loaded, self-peptide modified micelles revealed effective targeting to the tumor site while analysis of iron content demonstrated reduced particle accumulation in the liver and kidney, demonstrating reduced macrophage interaction, as well as a 2-fold increase of particles in the tumor. As these results demonstrate, Y1R ligand, self-peptide modified BPLP-WPU micelles are capable of target specific cancer treatment and imaging, making them ideal candidates to improve survival rate and tumor reduction clinically. (C) 2018 Elsevier Ltd. All rights reserved.
语种	英语
WOS记录号	WOS:000432903300007
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/29100]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Jiang, ZQ 2.Tian, YC 3.Shan, DY 4.Wang, YJ 5.Gerhard, E 6.Xia, JB 7.Huang, R 8.He, Y 9.Li, AG 10.Tang, JC
推荐引用方式 GB/T 7714	Jiang, ZQ,Tian, YC,Shan, DY,et al. pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time[J]. BIOMATERIALS,2018,170:70-81.
APA	Jiang, ZQ.,Tian, YC.,Shan, DY.,Wang, YJ.,Gerhard, E.,...&Wu, AG.(2018).pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time.BIOMATERIALS,170,70-81.
MLA	Jiang, ZQ,et al."pH protective Y-1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time".BIOMATERIALS 170(2018):70-81.