Nanoscale delivery systems for cancer immunotherapy

doi:10.1039/c7mh00991g

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Nanoscale delivery systems for cancer immunotherapy
	Wang, ZJ ; Liu, WH ; Shi, JY ; Chen, N ; Fan, CH
刊名	MATERIALS HORIZONS
	2018
卷号	5 期号:3 页码:344-362
关键词	Car-t-cells Antigen-presenting Cells Tumor-infiltrating Lymphocytes Membrane-coated Nanoparticles Iron-oxide Nanoparticles Enhanced Immune-response Virus-like Particles Drug-delivery Photothermal Therapy In-vivo
ISSN号	2051-6347
DOI	10.1039/c7mh00991g
文献子类	期刊论文
英文摘要	Increased understanding of tumor immunology has prompted rapid development of cancer immunotherapy in the past few years. The recent clinical success of immunotherapeutic approaches, such as immune checkpoint blockade and chimeric antigen receptor T cells, demonstrates their potential as a cancer terminator. Nevertheless, strategies to improve the overall efficiency and to reduce the side effects of immunotherapy are highly demanded. Nano-delivery systems hold great promise in biomedical applications due to their unique physiochemical properties and advantages in efficient tissue-specific delivery, enhanced cellular uptake and responsiveness to physiological and environmental stimuli. Immuno-nanomedicine opens a new field in cancer treatment and has attracted broad interest. In this review, we present recent advances in the field of cancer immunotherapy and focus on the nanocarrier-mediated delivery of immunomodulators as well as manipulation of immune cells. Applications of various types of nanomaterials (inorganic, polymers, liposomes, DNA-based, biomimetic and bio-derived nanoparticles) are summarized. Challenges and opportunities of nanovehicles in cancer immuno-oncology are also discussed.
语种	英语
WOS记录号	WOS:000431741300002
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/29081]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Wang, ZJ 2.Liu, WH 3.Shi, JY 4.Chen, N 5.Fan, CH
推荐引用方式 GB/T 7714	Wang, ZJ,Liu, WH,Shi, JY,et al. Nanoscale delivery systems for cancer immunotherapy[J]. MATERIALS HORIZONS,2018,5(3):344-362.
APA	Wang, ZJ,Liu, WH,Shi, JY,Chen, N,&Fan, CH.(2018).Nanoscale delivery systems for cancer immunotherapy.MATERIALS HORIZONS,5(3),344-362.
MLA	Wang, ZJ,et al."Nanoscale delivery systems for cancer immunotherapy".MATERIALS HORIZONS 5.3(2018):344-362.