Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions

doi:10.1021/jacs.7b04040

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions
	Qu, XM; Wang, SP; Ge, ZL; Wang, JB; Yao, GB; Li, J; Zuo, XL; Shi, JY; Song, SP; Wang, LH
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2017
卷号	139 期号:30 页码:10176-10179
关键词	Strand Displacement Cascades Dna Nanostructures Computation Microenvironments Amplification Monolayers Delivery Robots Array Ecm
ISSN号	0002-7863
DOI	10.1021/jacs.7b04040
文献子类	期刊论文
英文摘要	Programmable remodelling of cell surfaces enables high-precision regulation of cell behavior. In this work, we developed in vitro constructed DNA-based chemical reaction networks (CRNs) to program on-chip cell adhesion: We found that the RGD-functionalized DNA CRNs are entirely noninvasive when interfaced with the fluidic mosaic membrane of living cells. DNA toehold with different lengths could tunably alter the release kinetics of cells, which shows rapid release in minutes with the use of a 6-base toehold. We further demonstrated the realization of Boolean logic functions by using DNA strand displacement reactions, which include multi-input and sequential cell logic gates (AND, OR, XOR, and AND OR). This study provides a highly generic tool for self organization of biological systems.
WOS关键词	STRAND DISPLACEMENT CASCADES ; DNA NANOSTRUCTURES ; COMPUTATION ; MICROENVIRONMENTS ; AMPLIFICATION ; MONOLAYERS ; DELIVERY ; ROBOTS ; ARRAY ; ECM
语种	英语
WOS记录号	WOS:000407089500003
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/28785]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Qu, XM,Wang, SP,Ge, ZL,et al. Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017,139(30):10176-10179.
APA	Qu, XM.,Wang, SP.,Ge, ZL.,Wang, JB.,Yao, GB.,...&Fan, CH.(2017).Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,139(30),10176-10179.
MLA	Qu, XM,et al."Programming Cell Adhesion for On-Chip Sequential Boolean Logic Functions".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139.30(2017):10176-10179.