Influence of terminal substituents on the halide anion binding of foldamer-based receptors

	Influence of terminal substituents on the halide anion binding of foldamer-based receptors
	Yang, Ling 1,3; Zhao, Wei 1,3; Che, Yan-Ke 1; Wang, Ying 2; Jiang, Hua 1,2
刊名	CHINESE CHEMICAL LETTERS
	2017-08-01
卷号	28 期号:8 页码:1659-1662
关键词	Anion Binding Triazole Recognition Receptors Terminal Substituents
英文摘要	Foldamers 1-4 incorporating different terminal substituents have been designed and synthesized for binding halide anions. H-1 NMR titration experiments carried out in DMSO-d(6)/CDCl3 (15/85, viv) demonstrated that the short oligo(aryltriazole)s backbone 1 could not bind halide anions unless that amide H-bond donors were incorporated at the termini of the oligomer. Terminal substituents on oligo( aryltriazoleamide)s foldamers 2-4 display a considerable influence on the binding affinities of the foldamers for halide anions. Large steric hindrance of the terminal substituents was found to be unfavorable for binding halide anions, but aromatic 7t-n interactions between two terminal substituents are capable of stabilizing the conformation of foldamers thus giving rise to an enhancement in the binding strengths. However, the terminal substituents were found to hardly affect the binding selectivity in the studied cases. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/39202]
专题	化学研究所_光化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang, Ling,Zhao, Wei,Che, Yan-Ke,et al. Influence of terminal substituents on the halide anion binding of foldamer-based receptors[J]. CHINESE CHEMICAL LETTERS,2017,28(8):1659-1662.
APA	Yang, Ling,Zhao, Wei,Che, Yan-Ke,Wang, Ying,&Jiang, Hua.(2017).Influence of terminal substituents on the halide anion binding of foldamer-based receptors.CHINESE CHEMICAL LETTERS,28(8),1659-1662.
MLA	Yang, Ling,et al."Influence of terminal substituents on the halide anion binding of foldamer-based receptors".CHINESE CHEMICAL LETTERS 28.8(2017):1659-1662.