Catalytic Asymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate

	Catalytic Asymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate
	You, Yang'en 1,2,3; Zhang, Long 1,2,3; Cui, Linfeng 4; Mi, Xueling 4; Luo, Sanzhong 1,2,3
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2017-10-23
卷号	56 期号:44 页码:13814-13818
关键词	Amino Carbonyls Enamine Catalysis Imine Surrogate Mannich Reactions n O-acetals
英文摘要	N,O-acetals (NOAcs) were developed as bench stable surrogates for N-carbamoyl, (Boc, Cbz and Fmoc) formaldehyde and glyoxylate imines in asymmetric Mannich reactions. The NOAcs can be directly utilized in the chiral primary amine catalyzed Mannich reactions of both acyclic and cyclic beta-ketocarbonyls with high yields and excellent stereoselectivity. The current reaction offers a straightforward approach in the asymmetric synthesis of alpha- or beta-amino carbonyls bearing chiral quaternary centers in a practical and highly stereocontrolled manner.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/39173]
专题	化学研究所_分子识别与功能实验室
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, BNLMS, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100490, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China 4.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	You, Yang'en,Zhang, Long,Cui, Linfeng,et al. Catalytic Asymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(44):13814-13818.
APA	You, Yang'en,Zhang, Long,Cui, Linfeng,Mi, Xueling,&Luo, Sanzhong.(2017).Catalytic Asymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(44),13814-13818.
MLA	You, Yang'en,et al."Catalytic Asymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.44(2017):13814-13818.