Tumor Microenvironment-Triggered Aggregation of Antiphagocytosis Tc-99m-Labeled Fe3O4 Nanoprobes for Enhanced Tumor Imaging In Vivo

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	Tumor Microenvironment-Triggered Aggregation of Antiphagocytosis Tc-99m-Labeled Fe3O4 Nanoprobes for Enhanced Tumor Imaging In Vivo
	Gao, Zhenyu 1,2; Hou, Yi 2; Zeng, Jianfeng 3; Chen, Lei 3; Liu, Chunyan 2; Yang, Wensheng 1; Gao, Mingyuan 2,3,4
刊名	ADVANCED MATERIALS
	2017-06-27
卷号	29 期号:24
关键词	Antiphagocytosis Fe3o4 Nanoparticles Sensitive Mri Spect Imaging Tumor Microenvironment-triggered Aggregation
英文摘要	A tumor microenvironment responsive nanoprobe is developed for enhanced tumor imaging through in situ crosslinking of the Fe3O4 nanoparticles modified with a responsive peptide sequence in which a tumor-specific Arg-Gly-Asp peptide for tumor targeting and a self-peptide as a mark of self are linked through a disulfide bond. Positioning the self-peptide at the outmost layer is aimed at delaying the clearance of the nanoparticles from the bloodstream. After the self-peptide is cleaved by glutathione within tumor microenvironment, the exposed thiol groups react with the remaining maleimide moieties from adjacent particles to crosslink the particles in situ. Both in vitro and in vivo experiments demonstrate that the aggregation substantially improves the magnetic resonance imaging (MRI) contrast enhancement performance of Fe3O4 particles. By labeling the responsive particle probe with Tc-99m, single-photon emission computed tomography is enabled not only for verifying the enhanced imaging capacity of the crosslinked Fe3O4 particles, but also for achieving sensitive dual modality imaging of tumors in vivo. The novelty of the current probe lies in the combination of tumor microenvironment-triggered aggregation of Fe3O4 nanoparticles for boosting the T-2 MRI effect, with antiphagocytosis surface coating, active targeting, and dual-modality imaging, which is never reported before.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38901]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Jilin Univ, Coll Chem, Changchun 130012, Peoples R China 2.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China 3.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Ctr Mol Imaging & Nucl Med,Sch Radiol & Interdisc, Suzhou 215123, Peoples R China 4.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Gao, Zhenyu,Hou, Yi,Zeng, Jianfeng,et al. Tumor Microenvironment-Triggered Aggregation of Antiphagocytosis Tc-99m-Labeled Fe3O4 Nanoprobes for Enhanced Tumor Imaging In Vivo[J]. ADVANCED MATERIALS,2017,29(24).
APA	Gao, Zhenyu.,Hou, Yi.,Zeng, Jianfeng.,Chen, Lei.,Liu, Chunyan.,...&Gao, Mingyuan.(2017).Tumor Microenvironment-Triggered Aggregation of Antiphagocytosis Tc-99m-Labeled Fe3O4 Nanoprobes for Enhanced Tumor Imaging In Vivo.ADVANCED MATERIALS,29(24).
MLA	Gao, Zhenyu,et al."Tumor Microenvironment-Triggered Aggregation of Antiphagocytosis Tc-99m-Labeled Fe3O4 Nanoprobes for Enhanced Tumor Imaging In Vivo".ADVANCED MATERIALS 29.24(2017).