On the Origin of Ionic Rectification in DNA-Stuffed Nanopores: The Breaking and Retrieving Symmetry

	On the Origin of Ionic Rectification in DNA-Stuffed Nanopores: The Breaking and Retrieving Symmetry
	Jiang, Yanan 1; Feng, Yaping 2; Su, Jianjian 3; Nie, Jingxin 4; Cao, Liuxuan 3; Mao, Lanqun 1; Jiang, Lei 2; Guo, Wei 2
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2017-12-27
卷号	139 期号:51 页码:18739-18746
英文摘要	The discovery of ionic current rectification (ICR) phenomena in synthetic nanofluidic systems elicits broad interest from interdisciplinary fields of chemistry, physics, materials science, and nanotechnology; and thus, boosts their applications in, for example, chemical sensing, fluidic pumping, and energy related aspects. So far, it is generally accepted that the ICR effect stems from the broken symmetry either in the nanofluidic structures, or in the environmental conditions. Although this empirical regularity is supported by numerous experimental and theoretical results, great challenge still remains to precisely figure out the correlation between the asymmetric ion transport properties and the degree of symmetry breaking. An appropriate and quantified measure is therefore highly demanded. Herein, taking DNA-stuffed nanopores as a model system, we systematically investigate the evolution of dynamic ICR in between two symmetric states. The fully stuffed and fully opened nanopores are symmetric; therefore, they exhibit linear ion transport behaviors. Once the stuffed DNA superstructures are asymmetrically removed from one end of the nanopore via aptamer-target interaction, the nanofluidic system becomes asymmetric and starts to rectify ionic current. The peak of ICR is found right before the breakthrough of the stuffed DNA forest. After that, the nanofluidic system gradually retrieves symmetry, and becomes non rectified. Theoretical results by both the coarse-grained Poisson-Nernst-Planck model and the 1D statistic model excellently support the experimental observations, and further establish a quantified correlation between the ICR effect and the degree of asymmetry for different molecular filling configurations. Based on the ICR properties, we develop a proof-of-concept demonstration for sensing ATP, termed the ATP balance. These findings help to clarify the origin of ICR, and show implications to other asymmetric transport phenomena for future innovative nanofluidic devices and materials.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38468]
专题	化学研究所_活体分析化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Bioinspired Mat & Interfacial Sci, Beijing 100190, Peoples R China 3.Xiamen Univ, Coll Energy, Xiamen 361005, Fujian, Peoples R China 4.Peking Univ, Sch Phys, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Yanan,Feng, Yaping,Su, Jianjian,et al. On the Origin of Ionic Rectification in DNA-Stuffed Nanopores: The Breaking and Retrieving Symmetry[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017,139(51):18739-18746.
APA	Jiang, Yanan.,Feng, Yaping.,Su, Jianjian.,Nie, Jingxin.,Cao, Liuxuan.,...&Guo, Wei.(2017).On the Origin of Ionic Rectification in DNA-Stuffed Nanopores: The Breaking and Retrieving Symmetry.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,139(51),18739-18746.
MLA	Jiang, Yanan,et al."On the Origin of Ionic Rectification in DNA-Stuffed Nanopores: The Breaking and Retrieving Symmetry".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139.51(2017):18739-18746.