Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound

	Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound
	Chen, Waner 1,2,3,4; Yang, Yan 1,2; Shangguan, Dihua 5; Wu, Yuejing 6; Liu, Zhe 1,2,3,4
刊名	RSC ADVANCES
	2017
卷号	7 期号:42 页码:25892-25896
英文摘要	Polymeric microbubbles bearing a hard shell exhibit prominent stability and tunable acoustical properties that serve the purposes of biomedical imaging and ultrasound (US)-triggered cavitations. It is of great significance to expand the utility scope of hard-shelled microbubbles withmultifunctionality, which will dramatically enhance the efficiency and precision of disease-oriented treatments. To this end, the multifunctional hard-shelled microbubbles (PMBs) for US imaging and US-triggered stimuli-responsive cavitations have been synthesized via a one-step in situ polymerization. Varied parameters including US frequency, acoustical powers and pulse duration time have been screened to optimize the cavitation conditions. It was notable to observe that by use of PMBs, a US-triggered progress of imaging, stable and inertial cavitations could be easily differentiated with an elaborately modulated parameter, which gives a visualizable pathway for imaging, stimuli-responsive cavitation, drug transportation and release at each stage. Meanwhile, commercial US contrast agents (Sonovue and Xueruixin with lipid and protein shell materials) have been compared with PMBs in terms of their cavitation performances. These valuable findings imply a promising perspective to use these multifunctional microbubbles as a novel visualizable theranostic strategy against diseases.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38425]
专题	化学研究所_活体分析化学实验室
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Ultrason Diag, Wenzhou 325027, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China 3.Wenzhou Med Univ, Wenzhou Inst Biomat & Engn, Wenzhou 325001, Zhejiang, Peoples R China 4.Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou 325011, Zhejiang, Peoples R China 5.Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem,Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 6.Tianjin First Ctr Hosp, Tianjin 300192, Peoples R China
推荐引用方式 GB/T 7714	Chen, Waner,Yang, Yan,Shangguan, Dihua,et al. Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound[J]. RSC ADVANCES,2017,7(42):25892-25896.
APA	Chen, Waner,Yang, Yan,Shangguan, Dihua,Wu, Yuejing,&Liu, Zhe.(2017).Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound.RSC ADVANCES,7(42),25892-25896.
MLA	Chen, Waner,et al."Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound".RSC ADVANCES 7.42(2017):25892-25896.