Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition

	Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition
	Wang, Wenshuo 1,3; Cui, Haijun 1,3; Zhang, Pengchao 2,3; Meng, Jingxin 1; Zhang, Feilong 2,3; Wang, Shutao 1,3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-03-29
卷号	9 期号:12 页码:10537-10543
关键词	Biointerface Cancer Cell Recognition Topographic Interaction Cell Mineralization Hierarchical Structure
英文摘要	Cell-surface topographic interactions can direct the design of biointerfaces, which have been widely used in isolation of circulating tumor cells or fundamental cell biological research. By using three kinds of cancer cell-replicated surfaces with differentiated structures, we uncover that multiscale-cooperative topographic interactions (at both nanoscale and microscale) coupled with molecular recognition enable efficient and specific isolation of cancer cells. The cell replicas precisely inherit the structural features from the original cancer cells, providing not only preferable structures for matching with cancer cells but also a unique platform to interrogate whether certain cancer cells can optimally match with their own replicated surfaces. The results reveal that cancer cells do not show preferential recognitions to their respective replicas, while the capture agent-modified surfaces with hierarchical structures exhibit improved cancer cell capture efficiencies. Two levels of topographic interactions between cancer cells and cell replica surfaces exist. Nanoscale filopodia on cancer cells can topographically interact with different nanostructures on replica surfaces. In addition, microscale concave/convex on surfaces provide suitable sites for trapping cancer cells. This study may promote smart design of multiscale biofunctional materials that can specifically recognize cancer cells.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38240]
专题	化学研究所_有机固体实验室
作者单位	1.Chinese Acad Sci, CAS Ctr Excellence Nanosci, CAS Key Lab Bioinspired Mat & Interfacial Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Key Lab Organ Solids, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wenshuo,Cui, Haijun,Zhang, Pengchao,et al. Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(12):10537-10543.
APA	Wang, Wenshuo,Cui, Haijun,Zhang, Pengchao,Meng, Jingxin,Zhang, Feilong,&Wang, Shutao.(2017).Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition.ACS APPLIED MATERIALS & INTERFACES,9(12),10537-10543.
MLA	Wang, Wenshuo,et al."Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition".ACS APPLIED MATERIALS & INTERFACES 9.12(2017):10537-10543.