Near-infrared (NIR) controlled reversible cell adhesion on a responsive nano-biointerface

	Near-infrared (NIR) controlled reversible cell adhesion on a responsive nano-biointerface
	Cui, Haijun 1,2; Zhang, Pengchao 2,3; Wang, Wenshuo 1,2; Li, Guannan 2,3; Hao, Yuwei 2,3; Wang, Luying 2,3; Wang, Shutao 1,2
刊名	NANO RESEARCH
	2017-04-01
卷号	10 期号:4 页码:1345-1355
关键词	Cell Adhesion Photothermal Effect Nanostructures Bio-interface Hydrophobic Interaction
英文摘要	Light-activated dynamic variations have promoted the development of smart interfaces, especially nano-biointerfaces. In this article, the near-infrared (NIR)responsive surface for controlling cell adhesion was designed by grafting a thermal responsive polymer (poly(N-isopropylacrylamide), PNIPAM) onto silicon nanowires (SiNWs) instead of the traditional photosensitive moieties. NIR induced the photothermal effect of the SiNWs, and the local heat induced thermodynamic phase transformation of PNIPAM. With the application of NIR radiation, the surface turned to a hydrophobic state, and restored to the hydrophilic state when NIR was switched off, leading to reversible cell adhesion and release. The switchable wettability of the surface and cell adhesion/release occurred efficiently even after 20 cycles. Proteins were anchored on the surface via hydrophobic interactions using NIR; further connection of a cell-capture agent helped in achieving specific cell capture. This dynamic control of cell adhesion via NIR may provide new clues for designing functional nano-biointerfaces.
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/38239]
专题	化学研究所_有机固体实验室
作者单位	1.Chinese Acad Sci, CAS Key Lab Bioinspired Mat & Interfacial Sci, CAS Ctr Excellence Nanosci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cui, Haijun,Zhang, Pengchao,Wang, Wenshuo,et al. Near-infrared (NIR) controlled reversible cell adhesion on a responsive nano-biointerface[J]. NANO RESEARCH,2017,10(4):1345-1355.
APA	Cui, Haijun.,Zhang, Pengchao.,Wang, Wenshuo.,Li, Guannan.,Hao, Yuwei.,...&Wang, Shutao.(2017).Near-infrared (NIR) controlled reversible cell adhesion on a responsive nano-biointerface.NANO RESEARCH,10(4),1345-1355.
MLA	Cui, Haijun,et al."Near-infrared (NIR) controlled reversible cell adhesion on a responsive nano-biointerface".NANO RESEARCH 10.4(2017):1345-1355.