Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities

doi:10.1007/s12272-011-0501-9

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 中国科学院青藏高原研究所昆明部

	Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities
	Zhao, Yan-Li 2,4; Wang, Si-Feng 3; Li, Yang 2; He, Qiu-Xia 3; Liu, Ke-Chun 3; Yang, Yong-Ping1,2 ; Li, Xiao-Li 2
刊名	ARCHIVES OF PHARMACAL RESEARCH
	2011-05-01
卷号	34 期号:5 页码:703-707
关键词	Verbascum Thapsus Iridoid Nmr Antiangiogenic Activities Antiproliferative Activities A549
ISSN号	0253-6269
DOI	10.1007/s12272-011-0501-9
文献子类	Article
英文摘要	Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.; Phytochemical investigation of Verbascum thapsus led to the isolation and identification of one new iridoid compound named verbathasin A, along with ten known compounds. The structure and relative stereochemistry of verbathasin A were elucidated by analysis of spectroscopic data. All the isolates except 10-deoxyeucommiol and ajugol were tested for antiangiogenic and antiproliferative activities, and compounds luteolin and 3-O-fucopyranosylsaikogenin F showed promising antiproliferative activities, with an obvious effect of inducing apoptosis of A549 lung cancer cells.
学科主题	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	IRIDOID GLYCOSIDES
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000291365900003
资助机构	West Light Foundation of the Chinese Academy of Sciences ; MOST [2008BAD98B06]; MAPs Traditional Knowledge Network in Southwest China from MAPPA/ICIMOD ; Ford Foundation [1075-0729, 1090-0448]
公开日期	2011-12-06
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/2609]
专题	昆明植物研究所_中国科学院青藏高原研究所昆明部
作者单位	1.Chinese Acad Sci, Lab Ethnobot, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yan-Li,Wang, Si-Feng,Li, Yang,et al. Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities[J]. ARCHIVES OF PHARMACAL RESEARCH,2011,34(5):703-707.
APA	Zhao, Yan-Li.,Wang, Si-Feng.,Li, Yang.,He, Qiu-Xia.,Liu, Ke-Chun.,...&Li, Xiao-Li.(2011).Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities.ARCHIVES OF PHARMACAL RESEARCH,34(5),703-707.
MLA	Zhao, Yan-Li,et al."Isolation of Chemical Constituents from the Aerial Parts of Verbascum thapsus and Their Antiangiogenic and Antiproliferative Activities".ARCHIVES OF PHARMACAL RESEARCH 34.5(2011):703-707.