Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities

doi:10.1016/j.fitote.2018.06.019

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities
	Qin, Fu-Ying 1,2,3; Yan, Yong-Ming 2; Tu, Zheng-Chao 4; Cheng, Yong-Xian 1,2,5
刊名	FITOTERAPIA
	2018-09-01
卷号	129 页码:167-172
关键词	Ganoderma cochlear Meroterpenoids Computational methods Cytotoxicity COX-2
ISSN号	0367-326X
DOI	10.1016/j.fitote.2018.06.019
英文摘要	(+)- and (-)-Spirocochlealactones A-C (1-3), three pairs of new spiro meroterpenoidal dimeric enantiomers together with one known compound ganodilactone (4), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures including absolute configurations were assigned by using spectroscopic methods and ECD calculations. All the isolated compounds were tested for their COX-2 inhibitory and cytotoxic activities toward human cancer lines (A549, K562, and Huh-7). The results show that all the compounds could inhibit COX-2 with IC50 values in the range of 1.29 to 3.63 mu M. In addition, (+)-spirocochlealactone A and (+)-ganodilactone were found to be moderate activities against human cancer cell line A549 with the IC50 values of 7.14 and 9.47 mu M, respectively.
资助项目	National Science Fund for Distinguished Young Scholars[81525026] ; National Key Research and Development Program of China[2017YFA0503900] ; NSFC-Joint Foundation of Yunnan Province[U1702287] ; National Natural Science Foundation of China[21472199]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000443663800025
资助机构	National Science Fund for Distinguished Young Scholars ; National Key Research and Development Program of China ; NSFC-Joint Foundation of Yunnan Province ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/62299]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Cheng, Yong-Xian
作者单位	1.Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450008, Henan, Peoples R China 2.Shenzhen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Genome Stabil & Dis Prevent, Hlth Sci Ctr, Shenzhen 518060, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 5.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China
推荐引用方式 GB/T 7714	Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,et al. Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities[J]. FITOTERAPIA,2018,129:167-172.
APA	Qin, Fu-Ying,Yan, Yong-Ming,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2018).Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities.FITOTERAPIA,129,167-172.
MLA	Qin, Fu-Ying,et al."Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities".FITOTERAPIA 129(2018):167-172.