Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity

doi:10.1016/j.fitote.2018.07.007

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity
	Li, Jin-Yu 1,2; Yang, Liu 1; Hou, Bo 1,2; Ren, Fu-Cai 1,2; Yang, Xiao-Bei 1,2; Lv, Yong-Feng 1,2; Kuang, Meng-Ting 1,2; Hu, Jiang-Miao1 ; Zhou, Jun 1
刊名	FITOTERAPIA
	2018-09-01
卷号	129 页码:241-248
关键词	Bletilla ochracea Stilbenoids Bibenzyls Phenaothrenes Cytotoxicity
ISSN号	0367-326X
DOI	10.1016/j.fitote.2018.07.007
英文摘要	Ten previously undescribed stilbenoids, including six bibenzyls (bleochrins A-F, 1-6), three phenanthrenes derivatives (bleochrins G-J, 7-10) along with eleven known compounds were isolated from the rhizomes of Bletilla ochracea Schltr. The structural characterizations of 1-21 were accomplished by spectroscopic data, while the absolute stereostructure of 6 was confirmed by electronic circular dichroism (ECD) data analyses. All isolated metabolites except 7 were evaluated for cytotoxic activity against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480). Four isolates exhibited significant inhibitory ability against HL-60, SMMC-7721, and MCF-7 cell lines, with IC50 values ranging from 0.79 to 6.57 mu M. The isolates were tested further for inhibitory effects on the NO production of the liposaccharide (LPS)-induced RAW264.7 macrophages and showed activity with IC50 values at 15.29-24.02 mu M.
资助项目	Yunnan provincial science and technology department[2017ZF003] ; Yunnan provincial science and technology department[2015HB093] ; Yunnan provincial science and technology department[2018HA001]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000443663800036
资助机构	Yunnan provincial science and technology department
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/62297]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Hu, Jiang-Miao
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Jin-Yu,Yang, Liu,Hou, Bo,et al. Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity[J]. FITOTERAPIA,2018,129:241-248.
APA	Li, Jin-Yu.,Yang, Liu.,Hou, Bo.,Ren, Fu-Cai.,Yang, Xiao-Bei.,...&Zhou, Jun.(2018).Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity.FITOTERAPIA,129,241-248.
MLA	Li, Jin-Yu,et al."Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity".FITOTERAPIA 129(2018):241-248.