Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica

doi:10.1016/j.carbpol.2017.10.091

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica
	Liu, Jie1,2 ; Zhou, Lutan 1,3; He, Zhicheng 1,3; Gao, Na 1; Shang, Feineng 1; Xu, Jianping 1; Li, Zi 1; Yang, Zengming 2,4; Wu, Mingyi 1; Zhao, Jinhua1
刊名	CARBOHYDRATE POLYMERS
	2018-02-01
卷号	181 页码:433-441
关键词	Snail Glycosaminoglycan Chemical Structure Heparin Anticoagulant
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2017.10.091
英文摘要	Edible snails have been widely used as a health food and medicine in many countries. A unique glycosaminoglycan (AF-GAG) was purified from Achatina fulica. Its structure was analyzed and characterized by chemical and instrumental methods, such as Fourier transform infrared spectroscopy, analysis of monosaccharide composition, and 1D/2D nuclear magnetic resonance spectroscopy. Chemical composition analysis indicated that AF-GAG is composed of iduronic acid (IdoA) and N-acetyl-glucosamine (GlcNAc) and its average molecular weight is 118 kDa. Structural analysis clarified that the uronic acid unit in glycosaminoglycan (GAG) is the fully epimerized and the sequence of AF-GAG is -> 4)-alpha-GlcNAc (1 -> 4)-alpha-IdoA2S (1 ->. Although its structure with a uniform repeating disaccharide is similar to those of heparin and heparan sulfate, this GAG is structurally highly regular and homogeneous. Anticoagulant activity assays indicated that AF-GAG exhibits no anticoagulant activities, but considering its structural characteristic, other bioactivities such as heparanase inhibition may be worthy of further study.
语种	英语
WOS记录号	WOS:000418661000052
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/60604]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ TCM, Sch Pharm, Kunming 650500, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yunnan Inst Mat Med, Kunming 650500, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jie,Zhou, Lutan,He, Zhicheng,et al. Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica[J]. CARBOHYDRATE POLYMERS,2018,181:433-441.
APA	Liu, Jie.,Zhou, Lutan.,He, Zhicheng.,Gao, Na.,Shang, Feineng.,...&Zhao, Jinhua.(2018).Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica.CARBOHYDRATE POLYMERS,181,433-441.
MLA	Liu, Jie,et al."Structural analysis and biological activity of a highly regular glycosaminoglycan from Achatina fulica".CARBOHYDRATE POLYMERS 181(2018):433-441.