Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis

doi:10.1039/c7ra13309j

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis
	Pu, De-Bing1,3,4 ; Wang, Ting 2; Zhang, Xing-Jie 1; Gao, Jun-Bo 3,4; Zhang, Rui-Han 1; Li, Xiao-Nian 3; Wang, Yong-Mei 3,4; Li, Xiao-Li 1; Wang, He-Yao 2; Xiao, Wei-Lie 1,3
刊名	RSC ADVANCES
	2018
卷号	8 期号:12 页码:6425-6435
ISSN号	2046-2069
DOI	10.1039/c7ra13309j
英文摘要	Investigation of the leaves and stems of Premna szemaoensis resulted in the isolation of twelve new abietane diterpenoids, szemaoenoids A-L (1-12), together with four known abietane diterpenoids (13-16). The structures involved two rearranged-abietane skeletons: 17(15 -> 16)-abeo-abietane (7, 10-12, 14 and 15) and 17(15 -> 16), 18(4 -> 3)-diabeo-abietane (1-6, 13 and 16). The structures of the new compounds were established mainly by analyzing NMR and HRESIMS data. The absolute configurations of 1, 3 and 10 were confirmed by single crystal X-ray diffraction analysis. In bioactivity assays, compounds 11, 12, 14 and 15 were active against two human colon cancer cell lines (HCT-116 and HT-29) with IC50 values ranging from 8.8 to 34.3 mu M, and compounds 10, 13 and 14 exhibited effective free radical scavenging activity with IC50 values ranging from 35.6 to 41.5 mu M by DPPH experiment.
语种	英语
WOS记录号	WOS:000425034000030
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/60455]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, State Key Lab Conservat & Utilizat Bioresources Y, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650091, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Pu, De-Bing,Wang, Ting,Zhang, Xing-Jie,et al. Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis[J]. RSC ADVANCES,2018,8(12):6425-6435.
APA	Pu, De-Bing.,Wang, Ting.,Zhang, Xing-Jie.,Gao, Jun-Bo.,Zhang, Rui-Han.,...&Xiao, Wei-Lie.(2018).Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis.RSC ADVANCES,8(12),6425-6435.
MLA	Pu, De-Bing,et al."Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis".RSC ADVANCES 8.12(2018):6425-6435.