Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice

doi:10.1021/acs.jnatprod.7b00365

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice
	Xu, Yuhui 1,2; Niu, Yanfen 1,2,4; Gao, Yuan 5,6; Wang, Fang 1,2; Qin, Wanying 1,2; Lu, Yanting 1,2; Hu, Jing 1,2; Peng, Li 1,2; Liu, Jikai 3; Xiong, Wenyong1,2
刊名	JOURNAL OF NATURAL PRODUCTS
	2017-08-01
卷号	80 期号:8 页码:2319-2327
关键词	Insulin-resistance Tuberculata Beumee Metabolic Syndrome Srebp Liver Cholesterol Constituents Homeostasis Inhibition Receptors
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.7b00365
英文摘要	An insidious increase in the incidence of obesity, insulin resistance, and hyperlipidemia has led to an epidemic of type 2 diabetes worldwide. Tinospora crispa (T. crispa,) is a familiar plant traditionally used in herbal medicine for diabetes; however, the major active ingredients of this plant are still unclear. In this study, we identified the therapeutic effects of borapetoside E, a small molecule extracted from T. crispa, in high-fat-diet (HFD)-induced obesity in mice. The therapeutic effects of borapetoside E in HFD-induced obese mice were assessed physiologically, histologically, and biochemically following intraperitoneal injection. Furthermore, we analyzed the expression of glucose and lipid metabolism-related genes and proteins in borapetoside E-treated obese mice. Compared with vehicle-treated mice, borapetoside E markedly improved hyperglycemia, insulin resistance, hepatic steatosis, hyperlipidemia, and oxygen consumption in obese mice, and the effects were comparable to or better than the drug metformin. In addition, borapetoside E suppressed the expression of sterol regulatory element binding proteins (SREBPs) and their downstream target genes related to lipid synthesis in the liver and adipose tissue. Borapetoside E showed beneficial effects in vivo, demonstrating that borapetoside E may be a potential therapy for the treatment of diet-induced type 2 diabetes and related metabolic syndromes.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000408702600016
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/54928]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 4.Kunming Med Univ, Engn Res Ctr, Kunming 650500, Yunnan, Peoples R China 5.BioBioPha Co Ltd, Kunming 650201, Yunnan, Peoples R China 6.Yibin Univ, Dept Chem Engn, Yibin 644000, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yuhui,Niu, Yanfen,Gao, Yuan,et al. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(8):2319-2327.
APA	Xu, Yuhui.,Niu, Yanfen.,Gao, Yuan.,Wang, Fang.,Qin, Wanying.,...&Xiong, Wenyong.(2017).Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice.JOURNAL OF NATURAL PRODUCTS,80(8),2319-2327.
MLA	Xu, Yuhui,et al."Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice".JOURNAL OF NATURAL PRODUCTS 80.8(2017):2319-2327.