Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida

doi:10.1021/np9003855

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida
	Nian, Yin1,2 ; Zhang, Yan-Li 3; Chen, Jian-Chao 1; Lu, Lu 1,2; Qiu, Ming-Hua1 ; Qing, Chen 3
刊名	JOURNAL OF NATURAL PRODUCTS
	2010-02-01
卷号	73 期号:2 页码:93-98
关键词	Cinerascens Tetranortriterpenoids
ISSN号	0163-3864
DOI	10.1021/np9003855
文献子类	Article
英文摘要	Seven new 9,19-cycloartane triterpene glycosides. 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-D-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-D-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-D-xylopyranoside (4), 25-O-acetyl-12 beta-acetoxycimingenol-3-O-beta-D-xylopyranoside (5), 3'-O-acetylactein (6). and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds Showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29. and MKN28 cell lines. compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 mu M, respectively.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	CYCLOARTANE TRITERPENE SAPONINS ; SEQUENCE VARIATION ; BLACK COHOSH ; FOETIDA L ; GLYCOSIDES ; RACEMOSA ; ACTAEA ; PROLIFERATION ; RANUNCULACEAE ; PHYLOGENY
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000274803600001
资助机构	Foundation of the Key State Laboratory of Phytochemistry [P2008-ZZ05]; National Natural Science Foundation of China [30772636]; National Science Foundation of Yunnan Province [2005C0010Z]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4898]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China
推荐引用方式 GB/T 7714	Nian, Yin,Zhang, Yan-Li,Chen, Jian-Chao,et al. Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):93-98.
APA	Nian, Yin,Zhang, Yan-Li,Chen, Jian-Chao,Lu, Lu,Qiu, Ming-Hua,&Qing, Chen.(2010).Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida.JOURNAL OF NATURAL PRODUCTS,73(2),93-98.
MLA	Nian, Yin,et al."Cytotoxic Chemical Constituents from the Roots of Cimicifuga fetida".JOURNAL OF NATURAL PRODUCTS 73.2(2010):93-98.