Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major

doi:10.1016/j.phytochem.2010.04.013

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	Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major
	Chan, Hsiu-Hui 1; Sun, Han-Dong2 ; Reddy, Mopur Vijaya Bhaskar 1; Wu, Tian-Shung 1,3
刊名	PHYTOCHEMISTRY
	2010-08-01
卷号	71 期号:11-12 页码:1360-1364
关键词	Araliaceae PA.A. JA.oniC.s C. A. Meyer vA.. mA.or Zu-tziseng Polyacetylene Acarbose Alpha-glucosidase Inhibitors
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2010.04.013
文献子类	Article
英文摘要	Bioassay-guided fractionation of the CHCl(3) soluble portion of the roots of Panax japonicus C. A. Meyer var. major afforded an active fraction with inhibitory activity against baker's yeast alpha-glucosidase with an IC(50) value 1.02 mg/mL. Furthermore, the active fraction isolated contained three previously unreported polyacetylenes, designated panaxjapynes A-C, together with 11 other compounds, including four polyacetylenes, five phenolic compounds, a sesquiterpenoid, and a sterol glucoside. The structures of the compounds were elucidated by spectroscopic and chemical methods. Compared with the control acarbose (IC(50) 677.97 mu M), six compounds were shown to be more potent alpha-glucosidase inhibitors with IC(50) values in the range 22.21-217.68 mu M. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Plant Sciences
WOS关键词	ACTIVATES ESTROGEN-RECEPTOR ; CHEMICAL-CONSTITUENTS ; ABSOLUTE STRUCTURE ; ACID-DERIVATIVES ; GINSENG ; CELLS ; POLYACETYLENES ; FALCARINOL
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
WOS记录号	WOS:000280321000018
资助机构	National Science Council of Republic of China
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4866]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.China Med Univ, Dept Pharm, Taichung 40402, Taiwan
推荐引用方式 GB/T 7714	Chan, Hsiu-Hui,Sun, Han-Dong,Reddy, Mopur Vijaya Bhaskar,et al. Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major[J]. PHYTOCHEMISTRY,2010,71(11-12):1360-1364.
APA	Chan, Hsiu-Hui,Sun, Han-Dong,Reddy, Mopur Vijaya Bhaskar,&Wu, Tian-Shung.(2010).Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major.PHYTOCHEMISTRY,71(11-12),1360-1364.
MLA	Chan, Hsiu-Hui,et al."Potent alpha-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major".PHYTOCHEMISTRY 71.11-12(2010):1360-1364.