Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells

doi:10.1002/ptr.2671

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells
	Zeng, Guang-Zhi 1; Tan, Ning-Hua 1; Ji, Chang-Jiu 1,2; Fan, Jun-Ting 1,2; Huang, Huo-Qiang 1,2; Han, Hong-Jin 1; Zhou, Guang-Biao 3
刊名	PHYTOTHERAPY RESEARCH
	2009-06-01
卷号	23 期号:6 页码:885-891
关键词	Bigelovin Inula Helianthus-aquatica Cancer Cells Apoptosis U937
ISSN号	0951-418X
DOI	10.1002/ptr.2671
文献子类	Article
英文摘要	Inula helianthus-aquatica C. Y. Wu is a traditional medicinal plant used to treat some cancers in folk herbal medicine of Yunnan, China. Bigelovin, a sesquiterpene lactone isolated from this herb, potently inhibits the growth of a panel of eight cancer cell lines, especially in human monoblastic leukemia U937 cells with an IC(50) value of 0.47 mu M. Characteristic morphological features of apoptosis were observed in U937 cells treated with bigelovin. Annexin V and nuclear DNA content distribution assays showed that the percentage of Annexin V positive cells increased to 8.86% (24 h) with 1 mu M bigelovin treatment, and cells treated with bigelovin at this concentration apparently arrested at G(0)/G(1), phase compared with the control. These data suggested that cytotoxic effect of bigelovin on U937 cells involves induction of apoptosis, and the cell cycle is arrested at G(0)/G(1) phase. Copyright (C) 2008 John Wiley & Sons, Ltd.
学科主题	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	CANCER ; CYTOTOXICITY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000267088400024
资助机构	National Natural Science Foundation of China [30725048]; Foundation of Chinese Academy of Sciences [KSCX1-09-03-1, KSCX-SW-11]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4782]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Guang-Zhi,Tan, Ning-Hua,Ji, Chang-Jiu,et al. Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells[J]. PHYTOTHERAPY RESEARCH,2009,23(6):885-891.
APA	Zeng, Guang-Zhi.,Tan, Ning-Hua.,Ji, Chang-Jiu.,Fan, Jun-Ting.,Huang, Huo-Qiang.,...&Zhou, Guang-Biao.(2009).Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells.PHYTOTHERAPY RESEARCH,23(6),885-891.
MLA	Zeng, Guang-Zhi,et al."Apoptosis Inducement of Bigelovin from Inula helianthus-aquatica on Human Leukemia U937 Cells".PHYTOTHERAPY RESEARCH 23.6(2009):885-891.