Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase

doi:10.1007/s11418-006-0041-7

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
	Jo, Michiko ; Nakamura, Norio ; Kakiuchi, Nobuko ; Komatsu, Katsuko ; Qui, Ming-hua ; Shimotohno, Kumiko ; Shimotohno, Kunitada ; Hattori, Masao
刊名	JOURNAL OF NATURAL MEDICINES
	2006
卷号	60 期号:3 页码:217-224
关键词	Tripterygium Hypoglaucum Demethylzeylasteral Hepatitis c Virus Rna-dependent Rna Polymerase Yunnan Crude Drugs
ISSN号	1340-3443
DOI	10.1007/s11418-006-0041-7
通讯作者	Hattori, M, Toyama Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan
文献子类	Article
英文摘要	For the purpose of developing novel antihepatitis C virus (HCV) agents from natural resources, 93 Yunnan crude drugs were screened for their inhibitory effects on RNA-dependent RNA polymerase (RdRp) of HCV. Although 71 methanol extracts and 50 water extracts inhibited HCV-RdRp by more than 50% at a concentration of 50 mu g/ml, the majority of them contained a high percentage of tannins. However, methanol extracts of Plumbago zeylanica (branch), Maytenus fookerii (leaf) and Huashidancha (Y61, branch and leaf), and water extracts of Potentilla griffithii (whole plant) and Salva yunnanensis (underground part), having IC50 values of less than 10 mu g/ml, showed less than 10% tannin content. In addition, from a methanol extract of Tripterygium hypoglaucum (root bark), demethylzeylasteral was isolated as a strongly inhibitory Substance against HCV-RdRp.
学科主题	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000202947900007
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4760]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Toyama Univ, Inst Nat Med, Toyama 9300194, Japan 2.Kanazawa Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 4.Kyoritsu Univ Pharm, Minato Ku, Tokyo 1058512, Japan 5.Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Sakyo Ku, Kyoto 6068507, Japan
推荐引用方式 GB/T 7714	Jo, Michiko,Nakamura, Norio,Kakiuchi, Nobuko,et al. Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase[J]. JOURNAL OF NATURAL MEDICINES,2006,60(3):217-224.
APA	Jo, Michiko.,Nakamura, Norio.,Kakiuchi, Nobuko.,Komatsu, Katsuko.,Qui, Ming-hua.,...&Hattori, Masao.(2006).Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase.JOURNAL OF NATURAL MEDICINES,60(3),217-224.
MLA	Jo, Michiko,et al."Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase".JOURNAL OF NATURAL MEDICINES 60.3(2006):217-224.