Pregnane alkaloids from Pachysandra axillaris

doi:10.1016/j.steroids.2010.05.005

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Pregnane alkaloids from Pachysandra axillaris
	Sun, Yun 1,2,3; Yan, Yu-Xin 1,2; Chen, Jian-Chao 1; Lu, Lu 1,2; Zhang, Xian-Min 1; Li, Yan1 ; Qiu, Ming-Hua1
刊名	STEROIDS
	2010-12-01
卷号	75 期号:12 页码:818-824
关键词	Pregnane Alkaloids Pachysandra Axillaris Cytotoxic Activity
ISSN号	0039-128X
DOI	10.1016/j.steroids.2010.05.005
文献子类	Article
英文摘要	Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL-60, SMMC-7721, A549, SK-BR-3, and PANC-1 cell lines. Compound 15 possessed moderate activities against A-549, SK-BR-3, and PANC-1 cells, with the IC(50) values of 11.17, 4.17, and 10.76 mu M, respectively. Besides, compound 11 showed cytotoxicities against A-549 cell, with the IC(50) values as 24.94 mu M. (C) 2010 Published by Elsevier Inc.
学科主题	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
WOS记录号	WOS:000281932500004
资助机构	Foundation of Key State Lab. of Phytochemistry and Plant Resources in West China [P2008ZZ05]; CAS ; Chinese Academy of Sciences (CAS) [KSCX2-YW-G-038, KSCX2-YW-R-194, 29KZCX2-XB2-15-03]; National Natural Science Foundation of China [30772636]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4664]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Yunnan Univ Tradit Chinese Med, Kunming 650000, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yun,Yan, Yu-Xin,Chen, Jian-Chao,et al. Pregnane alkaloids from Pachysandra axillaris[J]. STEROIDS,2010,75(12):818-824.
APA	Sun, Yun.,Yan, Yu-Xin.,Chen, Jian-Chao.,Lu, Lu.,Zhang, Xian-Min.,...&Qiu, Ming-Hua.(2010).Pregnane alkaloids from Pachysandra axillaris.STEROIDS,75(12),818-824.
MLA	Sun, Yun,et al."Pregnane alkaloids from Pachysandra axillaris".STEROIDS 75.12(2010):818-824.