Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis

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	Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis
	Hou, AJ ; Fukai, T ; Shimazaki, M ; Sakagami, H ; Sun, HD; Nomura, T
刊名	JOURNAL OF NATURAL PRODUCTS
	2001
卷号	64 期号:1 页码:65-70
关键词	Cerebroside
ISSN号	0163-3864
通讯作者	Nomura, T, Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan
文献子类	Article
英文摘要	Four new benzophenones with two isoprenoid groups, cudraphenones A-D (1-4), and three new xanthones also with two isoprenoid units, cudraxanthones P-R (5-7), were isolated from the roots of Cudrania cochinchinensis, together with 19 known phenolic compounds. The structures of the new compounds were elucidated by spectroscopic methods. Some compounds exhibited weak cytotoxicity against human oral squamous carcinoma cells (HSC-8) and normal human gingival fibroblasts (HGF). Among them, benzophenones 1-4 showed more potent cytotoxic activities against HSC-2 cells than against HGF cells. On the other hand, xanthones bearing isoprenoid groups showed much lower tumor specificity as compared with the benzophenones, except for geronthxanthone H and isoalvaxanthone. The presence of two sets of hydrophobic and hydrophilic groups in separate domains in each molecule might play a role in the mediation of tumor-specific action.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	ROOT BARK ; SUBSTITUTED FLAVONOIDS ; POLYHYDROXY XANTHONES ; PRENYLATED XANTHONES ; MORACEOUS PLANTS ; CONSTITUENTS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000166696400014
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4548]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan 2.Meikai Univ Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283, Japan 3.Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Hou, AJ,Fukai, T,Shimazaki, M,et al. Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis[J]. JOURNAL OF NATURAL PRODUCTS,2001,64(1):65-70.
APA	Hou, AJ,Fukai, T,Shimazaki, M,Sakagami, H,Sun, HD,&Nomura, T.(2001).Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis.JOURNAL OF NATURAL PRODUCTS,64(1),65-70.
MLA	Hou, AJ,et al."Benzophenones and xanthones with isoprenoid groups from Cudrania cochinchinensis".JOURNAL OF NATURAL PRODUCTS 64.1(2001):65-70.