Chemical Constituents from the Leaves and Stems of Schisandra lancifolia | |
Xiao, Wei-Lie1; Yang, Liu-Meng2,3; Zhang, Hai-Bo1,4; Xue, Yong-Bo1,4; Yang, Guang-Yu1,5; Pu, Jian-Xin1; Wang, Rui-Rui2,3; Zheng, Yong-Tang2,3; Sun, Han-Dong1 | |
刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN |
2010-06-01 | |
卷号 | 58期号:6页码:852-855 |
关键词 | Nortriterpenoid Lignan Schisandra Lancifolia Anti-human Immunodeficiency Virus-1 Activity |
ISSN号 | 0009-2363 |
文献子类 | Article |
英文摘要 | A new nortriterpenoid, 20-hydroxymicrandilactone D (1) and a novel lignan glycoside, lancilignanside A (2) were isolated from leaves and stems of Schisandra lancifolia, together with three known nortriterpenoids (3-5) and nine known phenolics (6-14). The structures of new compounds 1 and 2 were determined by detailed analysis of their 1D and 2D NMR spectra, and chemical evidences. In addition, compounds 1-2, 6-7, and 9-11 showed anti-human immunodeficiency virus (HIV)-1 activities with 50% effective concentration (EC50) in the range of 3.0-99.0 mu g/ml. Compound 12 was not bioactive in this assay with EC50 more than 200 mu g/ml. |
学科主题 | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
WOS关键词 | ANTI-HIV ACTIVITY ; UNIQUE SKELETON ; C-13 NMR ; NORTRITERPENOIDS ; LIGNANS ; SCHISANARTANE ; TRITERPENOIDS ; FLAVONOIDS ; GLYCOSIDES ; MICRANTHA |
WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000278131700014 |
资助机构 | NSFC [20802082, 30830115]; Chinese Academy of Sciences [KSCX1-YW-R-24]; Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]; Major State Basic Research Development Program of China [2009CB522300, 2009CB940900] |
公开日期 | 2012-03-21 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn:8080/handle/151853/4124] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 3.Chinese Acad Sci, Lab Mol Immunopharmacol, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 5.Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 6501064, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Xiao, Wei-Lie,Yang, Liu-Meng,Zhang, Hai-Bo,et al. Chemical Constituents from the Leaves and Stems of Schisandra lancifolia[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(6):852-855. |
APA | Xiao, Wei-Lie.,Yang, Liu-Meng.,Zhang, Hai-Bo.,Xue, Yong-Bo.,Yang, Guang-Yu.,...&Sun, Han-Dong.(2010).Chemical Constituents from the Leaves and Stems of Schisandra lancifolia.CHEMICAL & PHARMACEUTICAL BULLETIN,58(6),852-855. |
MLA | Xiao, Wei-Lie,et al."Chemical Constituents from the Leaves and Stems of Schisandra lancifolia".CHEMICAL & PHARMACEUTICAL BULLETIN 58.6(2010):852-855. |
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