Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica

doi:10.1016/j.bmcl.2009.02.045

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	Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica
	Li, Jun-Zhu 1; Qing, Chen 2; Chen, Chang-Xiang1 ; Hao, Xiao-Jiang1 ; Liu, Hai-Yang1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2009-04-01
卷号	19 期号:7 页码:1956-1959
关键词	Asclepias Curassavica Asclepiadaceae Cardenolide Cardenolide Glycoside Cytotoxicity
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2009.02.045
文献子类	Article
英文摘要	A new cardenolide, 12 beta, 14 beta-dihydroxy-3 beta, 19-epoxy-3 alpha-methoxy-5 alpha-card-20(22)-enolide (6), and a new doubly linked cardenolide glycoside, 12 beta-hydroxycalotropin (13), together with eleven known compounds, coroglaucigenin (1), 12 beta-hydroxycoroglaucigenin (2), calotropagenin (3), desglucouzarin (4), 6'-O-feruloyl-desglucouzarin (5), calotropin (7), uscharidin (8), asclepin (9), 16 alpha-hydroxyasclepin (10), 16 alpha-acetoxycalotropin (11), and 16 alpha-acetoxyasclepin (12), were isolated from the aerial part of ornamental milkweed, Asclepias curassavica and chemically elucidated through spectral analyses. All the isolates were evaluated for their cytotoxic activity against HepG2 and Raji cell lines. The results showed that asclepin (9) had the strongest cytotoxic activity with an IC(50) value of 0.02 mu M against the two cancer cell lines and the new compound 13 had significant cytotoxic activity with IC(50) values of 0.69 and 1.46 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Medicinal ; Chemistry, Organic
WOS关键词	STEROIDAL GLYCOSIDES ; FRUTICOSA
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
WOS记录号	WOS:000264169700025
资助机构	Young Academic and Technical Leader Raising Foundation of Yunnan Province [2008PY066]
公开日期	2011-12-19
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/2901]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Kunming Med Coll, Yunnan Key Lab Pharmacol Nat Prod Res, Kunming 650031, Peoples R China
推荐引用方式 GB/T 7714	Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,et al. Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(7):1956-1959.
APA	Li, Jun-Zhu,Qing, Chen,Chen, Chang-Xiang,Hao, Xiao-Jiang,&Liu, Hai-Yang.(2009).Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(7),1956-1959.
MLA	Li, Jun-Zhu,et al."Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.7(2009):1956-1959.