Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity

doi:10.1021/np0704396

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity
	Chen, Jian-Chao 1; Zhang, Gao-Hong 2,3; Zhang, Zhong-Quan 1; Qiu, Ming-Hua1 ; Zheng, Yong-Tang 2,3; Yang, Liu-Meng 2,3; Yu, Kai-Bei 4
刊名	JOURNAL OF NATURAL PRODUCTS
	2008
卷号	71 期号:1 页码:153-155
关键词	Panacis-scandens Glycosides Rhizomes
ISSN号	0163-3864
DOI	10.1021/np0704396
文献子类	Article
英文摘要	Two new cucurbitacins, endecaphyllacins A (1) and B (2), together with six known analogues (3-8), were isolated from the tubers of Hemsleya endecaphylla. The structures of 1 and 2 were elucidated by NMR and MS spectroscopic analysis. The relative stereochemistry of I was determined by single-crystal X-ray diffraction. Compound 4 (cucurbitacin B) showed potent anti-HIV-1 in C8166 cells (EC = 0.09 mu g/mL) with a selectivity index of 16.7.
学科主题	Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
WOS关键词	PANACIS-SCANDENS ; GLYCOSIDES ; RHIZOMES
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000252629400034
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/1931]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Animal Models & Human Dis Mech, Kunming 650223, Yunan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunan, Peoples R China 4.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Chen, Jian-Chao,Zhang, Gao-Hong,Zhang, Zhong-Quan,et al. Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(1):153-155.
APA	Chen, Jian-Chao.,Zhang, Gao-Hong.,Zhang, Zhong-Quan.,Qiu, Ming-Hua.,Zheng, Yong-Tang.,...&Yu, Kai-Bei.(2008).Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity.JOURNAL OF NATURAL PRODUCTS,71(1),153-155.
MLA	Chen, Jian-Chao,et al."Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity".JOURNAL OF NATURAL PRODUCTS 71.1(2008):153-155.