Natural inhibitors of DNA topoisomerase I with cytotoxicities | |
Hong-Jin Han; Ning-Hua Tan; Guang-Zhi Zeng; Jun-Ting Fan; Huo-Qiang Huang; Chang-Jiu Ji; Rui-Rui Jia; Qin-Shi Zhao; Ying-Jun Zhang; Xiao-Jiang Hao | |
刊名 | CHEMISTRY & BIODIVERSITY |
2008 | |
卷号 | 5期号:7页码:1364-1368 |
关键词 | Salvia-miltiorrhiza Bunge Camptothecin Diterpenoids Flavones |
ISSN号 | 1612-1872 |
文献子类 | Article |
英文摘要 | DNA Topoisomerase I can cause DNA breaks and play a key role during cell proliferation and differentiation. It is an important target for anticancer agents. While screening for anticancer compounds, seven natural compounds, 1-7, showed potent cytotoxicities against a panel of ten cancer cell lines. Moreover, an inhibition assay demonstrated that they are also DNA topoisomerase I inhibitors, in which inhibitors 1-5 are new ones. |
学科主题 | Biochemistry & Molecular Biology ; Chemistry ; Multidisciplinary |
WOS关键词 | SALVIA-MILTIORRHIZA BUNGE ; CAMPTOTHECIN ; DITERPENOIDS ; FLAVONES |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000258089900015 |
公开日期 | 2011-11-24 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn:8080/handle/151853/1787] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
推荐引用方式 GB/T 7714 | Hong-Jin Han,Ning-Hua Tan,Guang-Zhi Zeng,et al. Natural inhibitors of DNA topoisomerase I with cytotoxicities[J]. CHEMISTRY & BIODIVERSITY,2008,5(7):1364-1368. |
APA | Hong-Jin Han.,Ning-Hua Tan.,Guang-Zhi Zeng.,Jun-Ting Fan.,Huo-Qiang Huang.,...&Li-Qin Wang.(2008).Natural inhibitors of DNA topoisomerase I with cytotoxicities.CHEMISTRY & BIODIVERSITY,5(7),1364-1368. |
MLA | Hong-Jin Han,et al."Natural inhibitors of DNA topoisomerase I with cytotoxicities".CHEMISTRY & BIODIVERSITY 5.7(2008):1364-1368. |
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