A small trypsin inhibitor from the frog of Odorrana grahami

doi:10.1016/j.biochi.2008.04.005

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	A small trypsin inhibitor from the frog of Odorrana grahami
	Li, Jianxu 1,4; Wu, Jing 1,4; Wang, Yipeng 2,4; Xu, Xueqing 2,4; Liu, Tongguang 1; Lai, Ren 1,2; Zhu, Huajie 3
刊名	BIOCHIMIE
	2008-09-01
卷号	90 期号:9 页码:1356-1361
关键词	Serine Protease Inhibitor Amphibian Odorrana Grahami
DOI	10.1016/j.biochi.2008.04.005
文献子类	Article
英文摘要	A novel peptide inhibitor (OGTI) of serine protease with a molecular weight of 1949.8, was purified from the skin secretion of the frog, Odorrana grahami. Of the tested serine proteases, OGTI only inhibited the hydrolysis activity of trypsin on synthetic chromogenic substrate. This precursor deduced from the cDNA sequence is composed of 70 amino acid residues. The mature OGTI contains 17 amino acid residues including a six-residue loop disulfided by two half-cysteines (AVNIPFKVHFRCKAAFC). In addition to its unique six-residue loop, the overall structure and precursor of OGTI are different from those of other serine protease inhibitors. It is also one of the smallest serine protease inhibitors ever found. (C) 2008 Elsevier Masson SAS. All rights reserved.
WOS关键词	SERINE-PROTEASE INHIBITORS ; TOAD BOMBINA-MAXIMA ; SKIN SECRETIONS ; MOLECULAR EVOLUTION ; PEPTIDES ; PRECURSOR ; CLONING ; FAMILY
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
WOS记录号	WOS:000259267700010
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/1701]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Biotoxin Units, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 2.Nanjing Agr Univ, Key Lab Microbiol Engn Agricultural Environm, Minist Agr, Life Sci Coll, Nanjing 210095, Jiangsu, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650224, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100009, Peoples R China
推荐引用方式 GB/T 7714	Li, Jianxu,Wu, Jing,Wang, Yipeng,et al. A small trypsin inhibitor from the frog of Odorrana grahami[J]. BIOCHIMIE,2008,90(9):1356-1361.
APA	Li, Jianxu.,Wu, Jing.,Wang, Yipeng.,Xu, Xueqing.,Liu, Tongguang.,...&Zhu, Huajie.(2008).A small trypsin inhibitor from the frog of Odorrana grahami.BIOCHIMIE,90(9),1356-1361.
MLA	Li, Jianxu,et al."A small trypsin inhibitor from the frog of Odorrana grahami".BIOCHIMIE 90.9(2008):1356-1361.