Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling
	Beevers, Christopher S.1; Zhou, Hongyu 2; Huang, Shile 3,4
刊名	ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
	2013-09-01
卷号	13 期号:7 页码:988-994
关键词	Curcumin Mtor Akt Cancer Cell Proliferation Cell Death
ISSN号	1871-5206
通讯作者	Beevers, CS (reprint author), Ross Univ, Dept Pharmacol, Sch Med, 630 US Hwy 1, North Brunswick, NJ 08902 USA. ; cbeevers@rossmed.edu.dm ; shuan1@lsuhsc.edu
文献子类	Article
英文摘要	The polyphenol natural product curcumin possesses a plethora of biological and pharmacological properties. For years, much interest has been placed in the development and use of curcumin and its derivatives for the prevention and treatment of cardiovascular, diabetic, and neurodegenerative diseases, as well as cancer. Increasing evidence suggests that curcumin displays amazing molecular versatility, and the number of its proposed cellular targets grows as the research continues. The mammalian target of rapamycin ( mTOR) is a master kinase, regulating cell growth/proliferation, survival, and motility. Dysregulated mTOR signaling occurs frequently in cancer, and targeting mTOR signaling is a promising strategy for cancer therapy. Recent studies have identified mTOR as a novel target of curcumin. Here we focus on reviewing current knowledge regarding the effects of curcumin on mTOR signaling for better understanding the anticancer mechanism of curcumin. The emerging studies of mTOR signaling and clinical studies on curcumin with cancer patients are also discussed here.
学科主题	Oncology ; Chemistry, Medicinal
WOS关键词	PROTEIN PHOSPHATASE 2A ; I CLINICAL-TRIAL ; P70 S6 KINASE ; MAMMALIAN TARGET ; AMINO-ACID ; TRANSLATION INITIATION ; INDEPENDENT PATHWAY ; CELL-PROLIFERATION ; CANCER-TREATMENT ; AKT ACTIVATION
WOS研究方向	Oncology ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000324249500004
资助机构	NIH [CA115414]; American Cancer Society [RSG-08-135-01-CNE]
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16665]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Ross Univ, Dept Pharmacol, Sch Med, Picard Portsmouth, Commonwealth Of, W Ind Assoc St 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan Province, Peoples R China 3.Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71105 USA 4.Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71105 USA
推荐引用方式 GB/T 7714	Beevers, Christopher S.,Zhou, Hongyu,Huang, Shile. Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,2013,13(7):988-994.
APA	Beevers, Christopher S.,Zhou, Hongyu,&Huang, Shile.(2013).Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,13(7),988-994.
MLA	Beevers, Christopher S.,et al."Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling".ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 13.7(2013):988-994.