Abietane Diterpenoids and a Lignan from Pinus yunnanensis

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Abietane Diterpenoids and a Lignan from Pinus yunnanensis
	Feng, Tao 1,2; Cai, Xiang-Hai1 ; Tan, Qin-Gang 1; Luo, Xiao-Dong1
刊名	ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
	2010-06-01
卷号	65 期号:6 页码:765-769
关键词	Pinus Yunnanensis Pinaceae Diterpenoids Lignan Anti-inflammatory Activity Cytotoxicity
ISSN号	0932-0776
文献子类	Article
英文摘要	Two new abietane diterpene acids, pinyunins A (1) and B (2), a new lignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(2,3-dihydroxyphenyl)propane-1,3-diol (3), and eight known diterpenoids (4-11) were isolated from the bark of Pinus yunnanensis Franch. Their structures were elucidated by spectroscopic methods. Compounds 1-3 exhibited high inhibitions on Cox-2 (> 80%) and low inhibitions on Cox-1 (< 50 %), showing the trend of selective inhibition of Cox-2, while the positive controls NS-398 (Cox-2) and SC-560 (Cox-1) gave inhibitions of 97.09% and 61.30%, respectively. Compounds 1-11 were evaluated for their cytotoxicity against five human cancer cell lines with Cisplatin as a positive control.
学科主题	Chemistry, Inorganic & Nuclear ; Chemistry, Organic
WOS关键词	METHIDE TUMOR INHIBITORS ; TAXODIUM DISTICHUM ; PROLIFERATION ; CONSTITUENTS ; TAXODONE ; RESIN
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000280568100014
公开日期	2012-07-25
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/14405]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Feng, Tao,Cai, Xiang-Hai,Tan, Qin-Gang,et al. Abietane Diterpenoids and a Lignan from Pinus yunnanensis[J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,2010,65(6):765-769.
APA	Feng, Tao,Cai, Xiang-Hai,Tan, Qin-Gang,&Luo, Xiao-Dong.(2010).Abietane Diterpenoids and a Lignan from Pinus yunnanensis.ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,65(6),765-769.
MLA	Feng, Tao,et al."Abietane Diterpenoids and a Lignan from Pinus yunnanensis".ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 65.6(2010):765-769.