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	Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals
	Zhang, Ling1,4; Luo, Rong-Hua2,3; Wang, Fei1; Dong, Ze-Jun1; Yang, Liu-Meng2,3; Zheng, Yong-Tang2,3; Liu, Ji-Kai1
刊名	PHYTOCHEMISTRY
	2010-11-01
卷号	71期号:16页码:1879-1883
关键词	Trigonostemon Thyrsoideum Euphorbiaceae Daphnane Diterpenoids Trigonothyrins D-g Anti-hiv-1
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2010.08.008
文献子类	Article
英文摘要	Four highly oxygenated daphnane diterpenoids, trigonothyrins D-G (1-4), were isolated from the stems of Trigonostemon thyrsoideum, and their structures were elucidated on the basis of extensive spectroscopic studies. Inhibitory activity against HIV-1 was assessed for compounds 1,3 and 4, wherein, 3 showed activity with an EC(50) value of 0.13 mu g/mL and a therapeutic index (TI) of 75.1. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Plant Sciences
WOS关键词	SYNAPTOLEPIS-KIRKII ; REIDIOIDES ; PLANT ; CHINENSIS ; REDIOCIDE ; ESTERS ; GENKWA ; ROOTS ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
WOS记录号	WOS:000283909200008
资助机构	National Natural Science Foundation of China [30830113]; National Basic Research Program of China (973 Program) [2009CB522300]; [2009ZX09501-029]; [2009ZX09501-013]
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/1505]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ling,Luo, Rong-Hua,Wang, Fei,et al. Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals[J]. PHYTOCHEMISTRY,2010,71(16):1879-1883.
APA	Zhang, Ling.,Luo, Rong-Hua.,Wang, Fei.,Dong, Ze-Jun.,Yang, Liu-Meng.,...&Liu, Ji-Kai.(2010).Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals.PHYTOCHEMISTRY,71(16),1879-1883.
MLA	Zhang, Ling,et al."Daphnane diterpenoids isolated from Trigonostemon thyrsoideum as HIV-1 antivirals".PHYTOCHEMISTRY 71.16(2010):1879-1883.

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