Mark-specific additive hazards regression with continuous marks

doi:10.1007/s10985-016-9369-9

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	Mark-specific additive hazards regression with continuous marks
	Han, Dongxiao 1; Sun, Liuquan1 ; Sun, Yanqing 2; Qi, Li 3
刊名	LIFETIME DATA ANALYSIS
	2017-07-01
卷号	23 期号:3 页码:467-494
关键词	Additive hazards model Competing risks Confidence bands and tests Continuous mark HIV vaccine trial Mark-specific vaccine effects Survival data
ISSN号	1380-7870
DOI	10.1007/s10985-016-9369-9
英文摘要	For survival data, mark variables are only observed at uncensored failure times, and it is of interest to investigate whether there is any relationship between the failure time and the mark variable. The additive hazards model, focusing on hazard differences rather than hazard ratios, has been widely used in practice. In this article, we propose a mark-specific additive hazards model in which both the regression coefficient functions and the baseline hazard function depend nonparametrically on a continuous mark. An estimating equation approach is developed to estimate the regression functions, and the asymptotic properties of the resulting estimators are established. In addition, some formal hypothesis tests are constructed for various hypotheses concerning the mark-specific treatment effects. The finite sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a data set from the first HIV vaccine efficacy trial is provided.
资助项目	National Natural Science Foundation of China[11231010] ; National Natural Science Foundation of China[11171330] ; Key Laboratory of RCSDS, CAS[2008DP173182] ; BCMIIS ; National Institutes of Health NIAID[R37 AI054165] ; National Science Foundation[DMS-1208978] ; National Science Foundation[DMS-1513072]
WOS研究方向	Mathematics
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000403359100007
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/25645]
专题	应用数学研究所
通讯作者	Sun, Liuquan
作者单位	1.Chinese Acad Sci, Inst Appl Math, Beijing 100190, Peoples R China 2.Univ North Carolina Charlotte, Dept Math & Stat, Charlotte, NC 28223 USA 3.Sanofi, Biostat & Programming, Bridgewater, NJ 08807 USA
推荐引用方式 GB/T 7714	Han, Dongxiao,Sun, Liuquan,Sun, Yanqing,et al. Mark-specific additive hazards regression with continuous marks[J]. LIFETIME DATA ANALYSIS,2017,23(3):467-494.
APA	Han, Dongxiao,Sun, Liuquan,Sun, Yanqing,&Qi, Li.(2017).Mark-specific additive hazards regression with continuous marks.LIFETIME DATA ANALYSIS,23(3),467-494.
MLA	Han, Dongxiao,et al."Mark-specific additive hazards regression with continuous marks".LIFETIME DATA ANALYSIS 23.3(2017):467-494.