Synthesis of PVP-functionalized ultra-small MoS2 nanoparticles with intrinsic peroxidase-like activity for H2O2 and glucose detection

doi:10.1039/c6ra18050g

	Synthesis of PVP-functionalized ultra-small MoS2 nanoparticles with intrinsic peroxidase-like activity for H2O2 and glucose detection
	Ma, XY; Yu J(余杰); Yu, J; Yin WY(尹文艳); Gu ZJ(谷战军); Yin, WY; Gu, ZJ
刊名	RSC ADVANCES
	2016
卷号	6 期号:84 页码:81174-81183
DOI	10.1039/c6ra18050g
通讯作者	尹文艳 ; 谷战军
英文摘要	Polyvinylpyrrolidone (PVP)-modified MoS2 nanoparticles (PVP-MoS2 NPs) with d - 5 nm and in high purity and yield were prepared by a facile one-pot hydrothermal method. Cytotoxicity and hemolysis studies demonstrated that PVP-MoS2 NPs show good biocompatibility. The PVP-MoS2 NPs exhibited remarkable peroxidase-like catalytic activity, which was similar to that of horseradish peroxidase (HRP). Based on this peroxidase-like activity, a platform for colorimetric detection of H2O2 was established. We have found that these NPs have high sensitivity to detect H2O2 with a nearly linear range between 2.0 x 10(-6) mol L-1 and 1.5 x 10(-4) mol L-1. Furthermore, the PVP-MoS2 NPs were also used for glucose measurement in serum by quantifying the released H2O2 in the presence of glucose oxidase. The linear range for glucose detection was from 1.0 x 10 (3) mol L-1 to 1.0 x 10(-2) mol L-1. This work will pave a way for the high-throughput synthesis of other ultra-small transition metal dichalcogenide (TMDs) NPs. Such enzyme-mimic nanomaterials could be a useful tool for medical diagnosis.
语种	英语
WOS记录号	WOS:000383903500094
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260484]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Ma, XY,Yu J,Yu, J,et al. Synthesis of PVP-functionalized ultra-small MoS2 nanoparticles with intrinsic peroxidase-like activity for H2O2 and glucose detection[J]. RSC ADVANCES,2016,6(84):81174-81183.
APA	Ma, XY.,余杰.,Yu, J.,尹文艳.,谷战军.,...&Gu, ZJ.(2016).Synthesis of PVP-functionalized ultra-small MoS2 nanoparticles with intrinsic peroxidase-like activity for H2O2 and glucose detection.RSC ADVANCES,6(84),81174-81183.
MLA	Ma, XY,et al."Synthesis of PVP-functionalized ultra-small MoS2 nanoparticles with intrinsic peroxidase-like activity for H2O2 and glucose detection".RSC ADVANCES 6.84(2016):81174-81183.