Quantitative chemical relations at pseudo-equilibrium in amorphous calcium phosphate formation

doi:10.1039/C6RA21892J

	Quantitative chemical relations at pseudo-equilibrium in amorphous calcium phosphate formation
	Zhang, Q; Liu, Y; Gou, BD; Zheng, L; Gao, YX; Zhang, TL; Zheng L(郑雷); Gao YX(高愈希)
刊名	RSC ADVANCES
	2016
卷号	6 期号:104 页码:102710-102723
DOI	10.1039/C6RA21892J
英文摘要	Amorphous calcium phosphate (ACP) is a precursor to crystalline hydroxyapatite, and has been found to be present in zebrafish and mouse bone formation. Most of the previous studies on ACP formation are qualititative in nature. Here, we report a quantitative correlation between the solution composition and the amount of ACP. Solutions with the initial Ca/P molar ratios between 0.5 and 1.5 were made either by fixing calcium and varying phosphate concentration (Series 1), or by fixing phosphate and varying calcium concentration (Series 2). From the two reaction series, we derived pseudo-equilibrium equations, and determined the threshold concentrations for ACP formation and its maximum amount, which are present as constants in these equations. Based on these results, we proposed a mechanism for ACP formation and derived the formation constant that depends on both the solution composition and the ACP amount. This work might represent an advance toward understanding the basic aspects of solution chemistry involving clusters and an amorphous phase of calcium phosphate, and the "two series" approach could be applicable to the systematical study of the amorphous phase of other sparingly soluble electrolytes. Moreover, these findings might provide new insight into the relevant physiological phenomena and be helpful for the rational design of functional materials.
语种	英语
WOS记录号	WOS:000387621700114
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260420]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhang, Q,Liu, Y,Gou, BD,et al. Quantitative chemical relations at pseudo-equilibrium in amorphous calcium phosphate formation[J]. RSC ADVANCES,2016,6(104):102710-102723.
APA	Zhang, Q.,Liu, Y.,Gou, BD.,Zheng, L.,Gao, YX.,...&高愈希.(2016).Quantitative chemical relations at pseudo-equilibrium in amorphous calcium phosphate formation.RSC ADVANCES,6(104),102710-102723.
MLA	Zhang, Q,et al."Quantitative chemical relations at pseudo-equilibrium in amorphous calcium phosphate formation".RSC ADVANCES 6.104(2016):102710-102723.