C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity

doi:10.1039/c6nr04875g

	C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity
	Guo, MZ; Pan YM(潘元明); Zhao YL(赵宇亮); Chen CY(陈春英); Pan, YM; Gao, D; Wang, LM; Wang LM(王黎明); Sun, CD; Zhao, YL
刊名	NANOSCALE
	2016
卷号	8 期号:36 页码:16332-16339
DOI	10.1039/c6nr04875g
通讯作者	陈春英
英文摘要	C-60(OH)(22) has been reported to suppress human cancer by inhibiting angiogenesis. However, its mechanism of action remains unclear. To explore the role and mechanism of C-60(OH)(22) in human pancreatic cancer, siRNA knockdown, immunofluorescence and a matrigel plug mouse model were employed. The results demonstrated that C-60(OH)(22) suppresses endothelial cell invasion and tube formation in vitro. C-60(OH)(22) suppresses angiogenesis in human umbilical vein endothelial cell (HUVEC) xenograft mice. The enzymatic activities of MMP2 and MMP9, as well as the expression levels of HDAC1, HDAC2, HIF-1 alpha and VEGF, were inhibited by C-60(OH)(22). The expression of RECK was up-regulated by C-60(OH)(22) in HUVECs. The expression levels of HIF-1 alpha and VEGF were down-regulated and the expression of RECK was up-regulated after the knockdown of HDAC1 and HDAC2 in HUVECs. Cell invasion, tube formation, and the enzymatic activities of MMP2 and MMP9 were suppressed after the knockdown of HDAC1 or HDAC2 in HUVECs.
语种	英语
WOS记录号	WOS:000384531600026
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260314]
专题	中国科学院高能物理研究所
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Guo, MZ,Pan YM,Zhao YL,et al. C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity[J]. NANOSCALE,2016,8(36):16332-16339.
APA	Guo, MZ.,潘元明.,赵宇亮.,陈春英.,Pan, YM.,...&Chen, CY.(2016).C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity.NANOSCALE,8(36),16332-16339.
MLA	Guo, MZ,et al."C-60(OH)(22): a potential histone deacetylase inhibitor with anti-angiogenic activity".NANOSCALE 8.36(2016):16332-16339.