Unfolding single RNA molecules by mechanical force: A stochastic kinetic method

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	Unfolding single RNA molecules by mechanical force: A stochastic kinetic method
	Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.; Liu, F; Ou-Yang, ZC
刊名	PHYSICAL REVIEW E
	2004
卷号	70 期号:4 页码:-
关键词	Titin Immunoglobulin Domains Secondary Structure Stranded-dna Protein Elasticity Simulation Algorithm Dynamics Models
ISSN号	1539-3755
英文摘要	Using simple polymer elastic theory and known RNA free energies, we study the single RNA folding and unfolding on the secondary structure level under mechanical constant force by stochastic kinetic simulation. As a primary application, this method is used to simulate the experiment performed by Liphardt et al. [Science 292, 733 (2001)]. The extension-force curves in equilibrium and kinetic reaction rate constants for folding and unfolding are calculated. Our results show that the agreement between simulation and experimental measurements is satisfactory.
学科主题	Physics
URL标识	查看原文
WOS记录号	WOS:000225689500006
公开日期	2012-08-30
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/13995]
专题	理论物理研究所_理论物理所1978-2010年知识产出
通讯作者	Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
推荐引用方式 GB/T 7714	Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.,Liu, F,Ou-Yang, ZC. Unfolding single RNA molecules by mechanical force: A stochastic kinetic method[J]. PHYSICAL REVIEW E,2004,70(4):-.
APA	Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.,Liu, F,&Ou-Yang, ZC.(2004).Unfolding single RNA molecules by mechanical force: A stochastic kinetic method.PHYSICAL REVIEW E,70(4),-.
MLA	Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.,et al."Unfolding single RNA molecules by mechanical force: A stochastic kinetic method".PHYSICAL REVIEW E 70.4(2004):-.