Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs

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	Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs
	Ou-Yang, Zhong-can; Xue, Xiao Chuan; Tong, Huan; Liu, Fei; Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
刊名	JOURNAL OF PHYSICAL CHEMISTRY B
	2008
卷号	112 期号:44 页码:13680-13683
关键词	Optical Tweezers Kinetics Models Dna
ISSN号	1520-6106
英文摘要	On the basis of a coarse-grain physical model of the folding and unfolding of single-forced RNAs conducted in light tweezer experiments, we theoretically investigate the feasibility of inferring the RNA's intrinsic kinetic parameters from the noisy time series of the molecule's extension. A Bayesian approach using Monte Carlo Markov Chain is proposed. We prove that this statistical approach is efficient and accurate in inferring the molecule's physical parameters, even if the experimental data are yielded under a narrow range of forces.
学科主题	Physics
URL标识	查看原文
WOS记录号	WOS:000260533100003
公开日期	2012-08-02
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/5440]
专题	理论物理研究所_理论物理所1978-2010年知识产出
通讯作者	Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Ou-Yang, Zhong-can,Xue, Xiao Chuan,Tong, Huan,et al. Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(44):13680-13683.
APA	Ou-Yang, Zhong-can,Xue, Xiao Chuan,Tong, Huan,Liu, Fei,&Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2008).Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs.JOURNAL OF PHYSICAL CHEMISTRY B,112(44),13680-13683.
MLA	Ou-Yang, Zhong-can,et al."Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs".JOURNAL OF PHYSICAL CHEMISTRY B 112.44(2008):13680-13683.