Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii

	Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii
	Pan, Li ; Zhou, Ping ; Zhang, Xiaofeng ; Peng, Shulin ; Ding, Lisheng ; Qiu, Samuel X.
刊名	organic letters
	2006-06-22
卷号	8 期号:13 页码:2775-2778
合作状况	其它
中文摘要	two novel rearranged trachylobane diterpenoids, designated as wallichanol a (2) and wallichanol b (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of euphorbia wallichii. their structures were elucidated by comprehensive analysis of 2d-nmr spectroscopic data, with the stereochemistry of 1 confirmed by x-ray crystallographic study. all of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis.
英文摘要	two novel rearranged trachylobane diterpenoids, designated as wallichanol a (2) and wallichanol b (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of euphorbia wallichii. their structures were elucidated by comprehensive analysis of 2d-nmr spectroscopic data, with the stereochemistry of 1 confirmed by x-ray crystallographic study. all of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis.
学科主题	生物科学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, organic
研究领域[WOS]	chemistry
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000238284500030
公开日期	2009-12-08
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/1325]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China 2.Washington Univ, Sch Med, St Louis, MO 63110 USA 3.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Pan, Li,Zhou, Ping,Zhang, Xiaofeng,et al. Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii[J]. organic letters,2006,8(13):2775-2778.
APA	Pan, Li,Zhou, Ping,Zhang, Xiaofeng,Peng, Shulin,Ding, Lisheng,&Qiu, Samuel X..(2006).Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.organic letters,8(13),2775-2778.
MLA	Pan, Li,et al."Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii".organic letters 8.13(2006):2775-2778.