Modeling and analysis of living beating cardiomyocyte in sub-cell scale

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	Modeling and analysis of living beating cardiomyocyte in sub-cell scale
	Liu LQ(刘连庆); Wang YC(王越超); Xi N(席宁); Wang WX(王文学); Zhang C(张闯)
	2017
会议名称	17th IEEE International Conference on Nanotechnology, NANO 2017
会议日期	July 25-28, 2017
会议地点	Pittsburgh, PA, United states
页码	406-410
通讯作者	Wang WX(王文学) ; Liu LQ(刘连庆)
中文摘要	The research on heart cells have attracted broad attention for the development of either heart disease therapy or muscle cell-based actuation for bio-syncretic robots. In order to study the mechanism and dynamics of beating activity of cardiomyocytes, many research methods have been proposed, such as the measurement of contractility and action potential of the cells. However, few of them has focused on the effect from the mechanical properties of sub-cell elements on the contraction performance of heart cells. In this work, a mechanical model of single heart cell was proposed based on the sub-cell structures, to study and control the contraction of the cardiomyocytes. The parameters of the parts in the theoretical model were identified with the cellular beating data obtained using Scanning Ion Conductance Microscopy (SICM) based on the derived mathematic model. Therefore, the contraction performance and the mechanical properties of sub-cell elements associated with the mechanical properties of parts in the model can be obtained for the further analysis of the relationship between the cell activity and sub-cell structures. This work is fundamental and meaningful for the research on cytobiology, heart mechanism and bio-syncretic robotics.
收录类别	EI ; CPCI（ISTP）
产权排序	1
会议主办者	IEEE Nanotechnology Council (NTC)
会议录	2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
会议录出版者	IEEE
会议录出版地	New York
语种	英语
ISBN号	978-1-5090-3028-6
WOS记录号	WOS:000434647500094
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/21544]
专题	沈阳自动化研究所_机器人学研究室
作者单位	1.University of Chinese Academy of Sciences, Beijing 100049, China 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China 3.Emerging Technologies Institute, Department of Industrial and Manufacturing Systems Engineering, University of Hong Kong, Pokfulam, Hong Kong
推荐引用方式 GB/T 7714	Liu LQ,Wang YC,Xi N,et al. Modeling and analysis of living beating cardiomyocyte in sub-cell scale[C]. 见:17th IEEE International Conference on Nanotechnology, NANO 2017. Pittsburgh, PA, United states. July 25-28, 2017.