Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives | |
Li, Zhi1,2; Yan, Chao3; Lv, Qin-yu4; Yi, Zheng-hui4; Zhang, Jian-ye5; Wang, Jin-hong5; Lui, Simon S. Y.6; Xu, Yi-feng4; Cheung, Eric F. C.6; Gur, Raquel E.7 | |
刊名 | SCHIZOPHRENIA RESEARCH |
2018-05-01 | |
卷号 | 195页码:215-221 |
关键词 | Schizophrenia First-degree Relative Dopamine Neural Circuits |
ISSN号 | 0920-9964 |
DOI | 10.1016/j.schres.2017.08.043 |
英文摘要 | Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. Hypoactivation in the dorsal striatum when anticipating monetary incentives were found in patients with schizophrenia and their unaffected first-degree relatives compared with healthy controls. Furthermore, patients with schizophrenia showed hyperactivation in the ventral striatum when receiving both monetary and affective incentives. These findings suggest that disorganized striatal function, regardless of incentive types, may be present in patients with schizophrenia and before the onset of illness in their first-degree unaffected relatives. (C) 2017 Elsevier B.V. All rights reserved. |
资助项目 | National Science Fund China[81571317] ; National Science Fund China[31500894] ; National Basic Research Program of China (Precision Psychiatry Programme)[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] |
WOS关键词 | Reward Anticipation ; Dorsal Striatum ; Linking Biology ; Activation ; Dopamine ; Prediction ; Psychosis ; Salience ; Phenomenology ; Dissociation |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000432466700031 |
资助机构 | National Science Fund China ; National Basic Research Program of China (Precision Psychiatry Programme) ; Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for Leading Talents in ST |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/26503] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.East China Normal Univ, Sch Psychol & Cognit Sci, Key Lab Brain Funct Genom MOE & STCSM, Shanghai, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China 5.Shanghai Mental Hlth Ctr, MRI Ctr, Shanghai, Peoples R China 6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 7.Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA |
推荐引用方式 GB/T 7714 | Li, Zhi,Yan, Chao,Lv, Qin-yu,et al. Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives[J]. SCHIZOPHRENIA RESEARCH,2018,195:215-221. |
APA | Li, Zhi.,Yan, Chao.,Lv, Qin-yu.,Yi, Zheng-hui.,Zhang, Jian-ye.,...&Chan, Raymond C. K..(2018).Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives.SCHIZOPHRENIA RESEARCH,195,215-221. |
MLA | Li, Zhi,et al."Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives".SCHIZOPHRENIA RESEARCH 195(2018):215-221. |
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