In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study

doi:10.1016/j.schres.2017.07.021

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	In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study
	Chiu, P. W.1,2; Lui, Simon S. Y.3,4; Hung, Karen S. Y.3; Chan, Raymond C. K.4,5,6 ; Chan, Queenie 7; Shamb, P. C.2,6; Cheung, Eric F. C.3; Mak, Henry K. F.1,2,8; H.K.F. Mak
刊名	SCHIZOPHRENIA RESEARCH
	2018-03-01
卷号	193 页码:295-303
关键词	Gamma-aminobutyric acid Glutamate First-episode schizophrenia Proton magnetic resonance spectroscopy Biomarker Anterior cingulate cortex
ISSN号	0920-9964
DOI	10.1016/j.schres.2017.07.021
产权排序	4
文献子类	Article
英文摘要	Background: Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic neurons. In this study, levels of GABA, Glx (summation of glutamate and glutamine), and other metabolites in the anterior cingulate cortex were measured and compared between first-episode schizophrenia subjects and healthy controls (HC). Diagnostic potential of GABA and Glx as upstream biomarkers for schizophrenia was explored.
WOS关键词	ANTERIOR CINGULATE CORTEX ; PREFRONTAL CORTEX ; GABA CONCENTRATION ; BIPOLAR DISORDER ; TISSUE SEGMENTATION ; MEDICATED PATIENTS ; POSTMORTEM-BRAIN ; GENE-EXPRESSION ; VISUAL-CORTEX ; FRONTAL LOBES
WOS研究方向	Psychiatry
语种	英语
WOS记录号	WOS:000427784100047
资助机构	University of Hong Kong(201511159189) ; Philip KH Wong Foundation ; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong ; Beijing Municipal Science & Technology Commission Grant(Z161100000216138) ; Beijing Training Project for Leading Talents in ST(Z151100000315020) ; National Basic Research Programme of China(2016YFC0906402)
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/26054]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	H.K.F. Mak
作者单位	1.Univ Hong Kong, Dept Diagnost Radiol, Hong Kong, Hong Kong, Peoples R China 2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China 3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 7.Philips Healthcare Hong Kong, Hong Kong, Hong Kong, Peoples R China 8.Univ Hong Kong, Alzheimers Dis Res Network, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Chiu, P. W.,Lui, Simon S. Y.,Hung, Karen S. Y.,et al. In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study[J]. SCHIZOPHRENIA RESEARCH,2018,193:295-303.
APA	Chiu, P. W..,Lui, Simon S. Y..,Hung, Karen S. Y..,Chan, Raymond C. K..,Chan, Queenie.,...&H.K.F. Mak.(2018).In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study.SCHIZOPHRENIA RESEARCH,193,295-303.
MLA	Chiu, P. W.,et al."In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study".SCHIZOPHRENIA RESEARCH 193(2018):295-303.