The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks

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	The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks
	He, Xingu 1,2; Bao, Yunfei 1; Li, Yonghui1 ; Sui, Nan1 ; Sui N(隋南)
刊名	NEUROSCIENCE LETTERS
	2010-09-20
卷号	482 期号:1 页码:12-16
关键词	Prenatal morphine exposure One-trial passive avoidance learning task Conditioned place preference Sensitive embryonic period Day-old chicks
ISSN号	0304-3940
文献子类	Article
英文摘要	Prenatal exposure to morphine can alter the capacities for learning and memory and the sensitivity to drugs of abuse in progeny. In the present study, we examined the effects of morphine during chick embryonic period of 5-8, 9-12, 13-16 and 17-20 on cognitive function and the sensitivities to morphine reward in the post-hatch chick, using the one-trial passive avoidance learning task and the conditioned place preference paradigm. It was observed that the injection of morphine (1 mg/kg of egg weight) during E5-8, but not in other three periods, significantly impaired intermediate- and long-term memory in one-day-old chicks. On the other hand, the chicks prenatally exposed to morphine during E17-20 remarkably not only acquired but also maintained the conditioned place preference induced by morphine. The present results suggest that there are two time-windows during development, which in the chick are around E5-8 and E17-20, when prenatal morphine exposure is likely to confer maximal risks for vulnerabilities to breakdown of memory consolidation and to morphine-induced reward in day-old chicks respectively. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
学科主题	认知神经科学
资助项目	一室隋南课题组
语种	英语
WOS记录号	WOS:000281274000003
公开日期	2011-12-02
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/7244]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Sui N(隋南)
作者单位	1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	He, Xingu,Bao, Yunfei,Li, Yonghui,et al. The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks[J]. NEUROSCIENCE LETTERS,2010,482(1):12-16.
APA	He, Xingu,Bao, Yunfei,Li, Yonghui,Sui, Nan,&隋南.(2010).The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks.NEUROSCIENCE LETTERS,482(1),12-16.
MLA	He, Xingu,et al."The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks".NEUROSCIENCE LETTERS 482.1(2010):12-16.