Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理研究所回溯数据库(1956-2010)

	Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats
	Wang, Ning1 ; Zhang, Yang 2; Wang, Jin-Yan1 ; Gao, Ge1 ; Luo, Fei1 ; Luo F(罗非)
刊名	NEUROSCIENCE BULLETIN
	2010-06-01
卷号	26 期号:3 页码:188-196
关键词	anesthesia laser, multiple single-unit recording
ISSN号	1673-7067
文献子类	Article
英文摘要	Objective To investigate the effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways. Methods Laser stimulation was employed to evoke nociceptive responses in rats under awake or anesthetic conditions. Pain-related neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with 4 eight-wire microelectrode arrays. Results Compared with the awake state, pentobarbital anesthesia significantly suppressed the neural activities induced by noxious laser stimulation. Meanwhile, the pain-evoked changes in the neuronal correlations between cortex and thalamus were suppressed in both medial and lateral pain pathways. In addition, the spontaneous firing rates in all the 4 areas were altered (including inhibition and excitation) under the condition of anesthesia. Conclusion The nociceptive processing in the brain can be dramatically changed by anesthesia, which indicates that there are considerable differences in the brain activities between awake and anesthetized states. It is better to employ awake animals for recording neural activity when investigating the sensory coding mechanisms, especially pain coding, in order to obtain data that precisely reflect the physiological state.
学科主题	健康心理学
资助项目	一室罗非课题组
语种	英语
WOS记录号	WOS:000295724200002
公开日期	2011-12-02
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/7228]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Luo F(罗非)
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ning,Zhang, Yang,Wang, Jin-Yan,et al. Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats[J]. NEUROSCIENCE BULLETIN,2010,26(3):188-196.
APA	Wang, Ning,Zhang, Yang,Wang, Jin-Yan,Gao, Ge,Luo, Fei,&罗非.(2010).Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats.NEUROSCIENCE BULLETIN,26(3),188-196.
MLA	Wang, Ning,et al."Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats".NEUROSCIENCE BULLETIN 26.3(2010):188-196.